Mark Chappell
Mark Chappell
Hypertension Center Wake Forest University School of Medicine
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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
K Kuba, Y Imai, S Rao, H Gao, F Guo, B Guan, Y Huan, P Yang, Y Zhang, ...
Nature medicine 11 (8), 875-879, 2005
Angiotensin-converting enzyme 2 is an essential regulator of heart function
MA Crackower, R Sarao, GY Oudit, C Yagil, I Kozieradzki, SE Scanga, ...
Nature 417 (6891), 822-828, 2002
Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2
CM Ferrario, J Jessup, MC Chappell, DB Averill, KB Brosnihan, EA Tallant, ...
Circulation 111 (20), 2605-2610, 2005
COVID-19, ACE2, and the cardiovascular consequences
AM South, DI Diz, MC Chappell
American Journal of Physiology-Heart and Circulatory Physiology, 2020
Counterregulatory actions of angiotensin-(1-7)
CM Ferrario, MC Chappell, EA Tallant, KB Brosnihan, DI Diz
Hypertension 30 (3), 535-541, 1997
Metabolism of angiotensin-(1–7) by angiotensin-converting enzyme
MC Chappell, NT Pirro, A Sykes, CM Ferrario
Hypertension 31 (1), 362-367, 1998
Inhibition of early atherogenesis by losartan in monkeys with diet-induced hypercholesterolemia
WB Strawn, MC Chappell, RH Dean, S Kivlighn, CM Ferrario
Circulation 101 (13), 1586-1593, 2000
Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration
CP Sodhi, C Wohlford-Lenane, Y Yamaguchi, T Prindle, WB Fulton, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 314 (1 …, 2018
Estrogen regulation of angiotensin-converting enzyme mRNA
PE Gallagher, P Li, JR Lenhart, MC Chappell, KB Brosnihan
Hypertension 33 (1), 323-328, 1999
Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia
HP Jia, DC Look, P Tan, L Shi, M Hickey, L Gakhar, MC Chappell, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 297 (1 …, 2009
Angiotensin-(1–7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide
P Li, MC Chappell, CM Ferrario, KB Brosnihan
Hypertension 29 (1), 394-398, 1997
Effects of renin-angiotensin system blockade on renal angiotensin-(1-7) forming enzymes and receptors
CM Ferrario, J Jessup, PE Gallagher, DB Averill, KB Brosnihan, ...
Kidney international 68 (5), 2189-2196, 2005
Angiotensin-(1–7) contributes to the antihypertensive effects of blockade of the renin-angiotensin system
SN Iyer, CM Ferrario, MC Chappell
Hypertension 31 (1), 356-361, 1998
Vasodepressor actions of angiotensin-(1–7) unmasked during combined treatment with lisinopril and losartan
SN Iyer, MC Chappell, DB Averill, DI Diz, CM Ferrario
Hypertension 31 (2), 699-705, 1998
Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice
GY Oudit, Z Kassiri, MP Patel, M Chappell, J Butany, PH Backx, ...
Cardiovascular research 75 (1), 29-39, 2007
Identification of angiotensin-(1-7) in rat brain: evidence for differential processing of angiotensin peptides
MC Chappell, KB Brosnihan, DI Diz, CM Ferrario
Journal of Biological Chemistry 264 (28), 16518-16523, 1989
Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?
MC Chappell
American Journal of Physiology-Heart and Circulatory Physiology 310 (2 …, 2016
Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure?
MC Chappell
Hypertension 50 (4), 596-599, 2007
Angiotensin-(1–7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats
IF Benter, MHM Yousif, GS Dhaunsi, J Kaur, MC Chappell, DI Diz
American journal of nephrology 28 (1), 25-33, 2007
Converting enzyme determines plasma clearance of angiotensin-(1–7)
K Yamada, SN Iyer, MC Chappell, D Ganten, CM Ferrario
Hypertension 32 (3), 496-502, 1998
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