AJ Sedgewick
AJ Sedgewick
Senior Computational Systems Biologist, Tempus Labs
E-mailová adresa ověřena na:
Transcriptional programming of normal and inflamed human epidermis at single-cell resolution
JB Cheng, AJ Sedgewick, AI Finnegan, P Harirchian, J Lee, S Kwon, ...
Cell reports 25 (4), 871-883, 2018
Learning mixed graphical models with separate sparsity parameters and stability-based model selection
AJ Sedgewick, I Shi, RM Donovan, PV Benos
BMC bioinformatics 17, 307-318, 2016
Mixed graphical models for integrative causal analysis with application to chronic lung disease diagnosis and prognosis
AJ Sedgewick, K Buschur, I Shi, JD Ramsey, VK Raghu, DV Manatakis, ...
Bioinformatics 35 (7), 1204-1212, 2019
Efficient stochastic simulation of chemical kinetics networks using a weighted ensemble of trajectories
RM Donovan, AJ Sedgewick, JR Faeder, DM Zuckerman
The Journal of chemical physics 139 (11), 2013
Learning subgroup-specific regulatory interactions and regulator independence with PARADIGM
AJ Sedgewick, SC Benz, S Rabizadeh, P Soon-Shiong, CJ Vaske
Bioinformatics 29 (13), i62-i70, 2013
Single-cell profiling reveals divergent, globally patterned immune responses in murine skin inflammation
Y Liu, C Cook, AJ Sedgewick, S Zhang, MS Fassett, ...
Iscience 23 (10), 2020
Validation of genomic and transcriptomic models of homologous recombination deficiency in a real-world pan-cancer cohort
BD Leibowitz, BV Dougherty, JSK Bell, J Kapilivsky, J Michuda, ...
BMC cancer 22 (1), 587, 2022
Large scale, robust, and accurate whole transcriptome profiling from clinical formalin-fixed paraffin-embedded samples
Y Newton, AJ Sedgewick, L Cisneros, J Golovato, M Johnson, CW Szeto, ...
Scientific reports 10 (1), 17597, 2020
PARP1 rs1805407 increases sensitivity to PARP1 inhibitors in cancer cells suggesting an improved therapeutic strategy
I Abecassis, AJ Sedgewick, M Romkes, S Buch, T Nukui, MG Kapetanaki, ...
Scientific reports 9 (1), 3309, 2019
Data-independent acquisition mass spectrometry to quantify protein levels in FFPE tumor biopsies for molecular diagnostics
YJ Kim, SMM Sweet, JD Egertson, AJ Sedgewick, S Woo, W Liao, ...
Journal of proteome research 18 (1), 426-435, 2018
Regional molecular signature of the symptomatic atherosclerotic carotid plaque
EM Caparosa, AJ Sedgewick, G Zenonos, Y Zhao, DL Carlisle, ...
Neurosurgery 85 (2), E284-E293, 2019
A20 and ABIN1 suppression of a keratinocyte inflammatory program with a shared single-cell expression signature in diverse human rashes
P Harirchian, J Lee, S Hilz, AJ Sedgewick, BEP White, MJ Kesling, T Mully, ...
Journal of Investigative Dermatology 139 (6), 1264-1273, 2019
A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity
CP Cook, M Taylor, Y Liu, R Schmidt, A Sedgewick, E Kim, A Hailer, ...
Cell Reports Medicine 3 (8), 2022
Mixed graphical models for causal analysis of multi-modal variables
AJ Sedgewick, JD Ramsey, P Spirtes, C Glymour, PV Benos
arXiv preprint arXiv:1704.02621, 2017
Investigating tumoral and temporal heterogeneity through comprehensive-omics profiling in patients with metastatic triple negative breast cancer.
C Szeto, R Parulkar, AJ Sedgewick, SC Benz, F Cecchi, TA Hembrough, ...
Journal of Clinical Oncology 35 (15_suppl), 1093-1093, 2017
Graphical models for de novo and pathway-based network prediction over multi-modal high-throughput biological data
AJ Sedgewick
University of Pittsburgh, 2016
Comprehensive proteomic and genomic profiling to identify therapeutic targets in adenoid cystic carcinoma.
SP Thyparambil, YJ Kim, A Chambers, D Yan, S Sellappan, C Gong, ...
Journal of Clinical Oncology 36 (15_suppl), 6053-6053, 2018
A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa
K Van Loon, EJ Mmbaga, BP Mushi, M Selekwa, A Mwanga, LO Akoko, ...
Cancer Epidemiology, Biomarkers & Prevention 32 (10), 1411-1420, 2023
Potential drug targets for adenoid cystic carcinoma elucidated by proteogenomic analysis
SP Thyparambil, YJ Kim, AG Chambers, D Yan, S Sellappan, ...
Cancer Research 78 (13_Supplement), 778-778, 2018
Systems And Methods For Learning And Identification Of Regulatory Interactions In Biological Pathways
CJ Vaske, AJ Sedgewick, SC Benz
US Patent App. 14/434,745, 2015
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Články 1–20