Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4 CA Lyssiotis, RK Foreman, J Staerk, M Garcia, D Mathur, S Markoulaki, ... Proceedings of the National Academy of Sciences 106 (22), 8912-8917, 2009 | 493 | 2009 |
A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling MJ Bollong, G Lee, JS Coukos, H Yun, C Zambaldo, JW Chang, EN Chin, ... Nature 562 (7728), 600-604, 2018 | 229 | 2018 |
Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells A Chatterjee, H Xiao, M Bollong, HW Ai, PG Schultz Proceedings of the National Academy of Sciences 110 (29), 11803-11808, 2013 | 134 | 2013 |
A small molecule inhibits deregulated NRF2 transcriptional activity in cancer MJ Bollong, H Yun, L Sherwood, AK Woods, LL Lairson, PG Schultz ACS chemical biology 10 (10), 2193-2198, 2015 | 94 | 2015 |
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers MJ Bollong, M Pietilä, AD Pearson, TR Sarkar, I Ahmad, R Soundararajan, ... Proceedings of the National Academy of Sciences 114 (46), E9903-E9912, 2017 | 75 | 2017 |
2-Sulfonylpyridines as tunable, cysteine-reactive electrophiles C Zambaldo, EV Vinogradova, X Qi, J Iaconelli, RM Suciu, M Koh, ... Journal of the American Chemical Society 142 (19), 8972-8979, 2020 | 72 | 2020 |
Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis MJ Bollong, B Yang, N Vergani, BA Beyer, EN Chin, C Zambaldo, D Wang, ... Proceedings of the National Academy of Sciences 114 (18), 4679-4684, 2017 | 69 | 2017 |
Pan‐Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells J Staerk, CA Lyssiotis, LA Medeiro, M Bollong, RK Foreman, S Zhu, ... Angewandte Chemie International Edition 50 (25), 5734-5736, 2011 | 58 | 2011 |
Targeted delivery of an anti-inflammatory PDE4 inhibitor to immune cells via an antibody–drug conjugate S Yu, AD Pearson, RKV Lim, DT Rodgers, S Li, HB Parker, M Weglarz, ... Molecular Therapy 24 (12), 2078-2089, 2016 | 50 | 2016 |
Deconvoluting stress-responsive proteostasis signaling pathways for pharmacologic activation using targeted RNA sequencing JMD Grandjean, L Plate, RI Morimoto, MJ Bollong, ET Powers, ... ACS chemical biology 14 (4), 784-795, 2019 | 44 | 2019 |
A short ORF-encoded transcriptional regulator M Koh, I Ahmad, Y Ko, Y Zhang, TF Martinez, JK Diedrich, Q Chu, ... Proceedings of the National Academy of Sciences 118 (4), e2021943118, 2021 | 37 | 2021 |
Defining the functional targets of Cap ‘n’collar transcription factors NRF1, NRF2, and NRF3 L Ibrahim, J Mesgarzadeh, I Xu, ET Powers, RL Wiseman, MJ Bollong Antioxidants 9 (10), 1025, 2020 | 33 | 2020 |
YAP-dependent proliferation by a small molecule targeting annexin A2 SZ Shalhout, PY Yang, EM Grzelak, K Nutsch, S Shao, C Zambaldo, ... Nature Chemical Biology 17 (7), 767-775, 2021 | 29 | 2021 |
A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer NC Lucki, GR Villa, N Vergani, MJ Bollong, BA Beyer, JW Lee, JL Anglin, ... Proceedings of the National Academy of Sciences 116 (13), 6435-6440, 2019 | 27 | 2019 |
CRY2 missense mutations suppress P53 and enhance cell growth AB Chan, GCG Parico, JL Fribourgh, LH Ibrahim, MJ Bollong, CL Partch, ... Proceedings of the National Academy of Sciences 118 (27), e2101416118, 2021 | 24 | 2021 |
Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer M Pariollaud, LH Ibrahim, E Irizarry, RM Mello, AB Chan, BJ Altman, ... Science Advances 8 (39), eabo1123, 2022 | 21 | 2022 |
Metabolically activated proteostasis regulators protect against glutamate toxicity by activating NRF2 JD Rosarda, KR Baron, K Nutsch, GM Kline, C Stanton, JW Kelly, ... ACS Chemical Biology 16 (12), 2852-2863, 2021 | 16 | 2021 |
Small molecule inhibitors of fibrosis L Lairson, M Bollong, PG Schultz, AK Chatterjee, Y Baiyuan, P Kumar, ... US Patent 9,981,956, 2018 | 11 | 2018 |
S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling Y Ko, M Hong, S Lee, M Kumar, L Ibrahim, K Nutsch, C Stanton, ... Proceedings of the National Academy of Sciences 120 (20), e2300763120, 2023 | 9 | 2023 |
Succinylation of a KEAP1 sensor lysine promotes NRF2 activation L Ibrahim, C Stanton, K Nutsch, T Nguyen, C Li-Ma, Y Ko, GC Lander, ... Cell Chemical Biology 30 (10), 1295-1302. e4, 2023 | 6 | 2023 |