| The role of protein-protein and protein-membrane interactions on P450 function EE Scott, CR Wolf, M Otyepka, SC Humphreys, JR Reed, CJ Henderson, ... Drug metabolism and disposition 44 (4), 576-590, 2016 | 42 | 2016 |
| The two faces of aldehyde oxidase: oxidative and reductive transformations of 5-nitroquinoline EM Paragas, SC Humphreys, J Min, CA Joswig-Jones, JP Jones Biochemical Pharmacology 145, 210-217, 2017 | 24 | 2017 |
| Tracking individual membrane proteins and their biochemistry: The power of direct observation AO Barden, AS Goler, SC Humphreys, S Tabatabaei, M Lochner, ... Neuropharmacology 98, 22-30, 2015 | 18 | 2015 |
| Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs N Bai, KM Riching, A Makaju, H Wu, TM Acker, SC Ou, Y Zhang, X Shen, ... Journal of Biological Chemistry 298 (4), 2022 | 16 | 2022 |
| Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA SC Humphreys, MB Thayer, JM Lade, B Wu, K Sham, B Basiri, Y Hao, ... Drug Metabolism and Disposition 47 (10), 1174-1182, 2019 | 13 | 2019 |
| Quantification of siRNA-antibody conjugates in biological matrices by triplex-forming oligonucleotide ELISA SC Humphreys, MB Thayer, IDG Campuzano, C Netirojjanakul, BM Rock nucleic acid therapeutics 29 (3), 161-166, 2019 | 11 | 2019 |
| ecoAO: a simple system for the study of human aldehyde oxidases role in drug metabolism EM Paragas, SC Humphreys, J Min, CA Joswig-Jones, S Leimkühler, ... ACS omega 2 (8), 4820-4827, 2017 | 11 | 2017 |
| Emerging siRNA design principles and consequences for biotransformation and disposition in drug development SC Humphreys, MB Thayer, J Campbell, WLK Chen, D Adams, JM Lade, ... Journal of Medicinal Chemistry 63 (12), 6407-6422, 2020 | 9 | 2020 |
| Substrate Dependent Native Luminescence from Cytochromes P450 3A4, 2C9, and P450cam C Barnaba, SC Humphreys, AO Barden, JP Jones, JA Brozik The Journal of Physical Chemistry B 120 (12), 3038-3047, 2016 | 9 | 2016 |
| Introducing an in vitro liver stability assay capable of predicting the in vivo pharmacodynamic efficacy of siRNAs for IVIVC B Basiri, F Xie, B Wu, SC Humphreys, JM Lade, MB Thayer, P Yamaguchi, ... Molecular Therapy-Nucleic Acids 21, 725-736, 2020 | 8 | 2020 |
| Prolonged cultured human hepatocytes as an in vitro experimental system for the evaluation of potency and duration of activity of RNA therapeutics: Demonstration of prolonged … Q Yang, SC Humphreys, JM Lade, AP Li Biochemical Pharmacology 189, 114374, 2021 | 7 | 2021 |
| POE Immunoassay: Plate-based oligonucleotide electro-chemiluminescent immunoassay for the quantification of nucleic acids in biological matrices MB Thayer, SC Humphreys, KS Chung, JM Lade, KD Cook, BM Rock Scientific reports 10 (1), 1-9, 2020 | 7 | 2020 |
| Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics D Ramsden, DG Belair, S Agarwal, P Andersson, S Humphreys, ... ALTEX-Alternatives to animal experimentation 39 (2), 273-296, 2022 | 6 | 2022 |
| Considerations and recommendations for assessment of plasma protein binding and drug–drug interactions for siRNA therapeutics SC Humphreys, JA Davis, S Iqbal, A Kamel, K Kulmatycki, Y Lao, X Liu, ... Nucleic acids research 50 (11), 6020-6037, 2022 | 3 | 2022 |
| Half-Life extension of Peptidic APJ agonists by N-Terminal lipid conjugation AB Reed, BA Lanman, JR Holder, BH Yang, J Ma, SC Humphreys, ... Bioorganic & Medicinal Chemistry Letters 30 (21), 127499, 2020 | 2 | 2020 |
| Case study 12: roadmap to quantifying ago2-mediated siRNA metabolic activation kinetics SC Humphreys, B Basiri, A Abbasi, BM Rock Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, 825-841, 2021 | 1 | 2021 |
| Microphysiological endothelial models to characterize subcutaneous drug absorption GS Offeddu, JC Serrano, Z Wan, MA Bryniarski, SC Humphreys, SW Chen, ... ALTEX-Alternatives to animal experimentation, 2022 | | 2022 |
| Detection assay for protein-polynucleotide conjugates M Thayer, S Humphreys US Patent App. 17/537,378, 2022 | | 2022 |
| Non‐transporter mediated drug permeability across MDCK cell monolayers: Towards an explicit definition of the partition constant for passive drug interactions with cell membranes S Humphreys The FASEB Journal 30, lb547-lb547, 2016 | | 2016 |
| Deconvoluting the dance of the cytochrome P450 metabolon at the lipid bilayer SC Humphreys Washington State University, 2016 | | 2016 |
