Sara C Humphreys
Sara C Humphreys
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The role of protein-protein and protein-membrane interactions on P450 function
EE Scott, CR Wolf, M Otyepka, SC Humphreys, JR Reed, CJ Henderson, ...
Drug metabolism and disposition 44 (4), 576-590, 2016
Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs
N Bai, KM Riching, A Makaju, H Wu, TM Acker, SC Ou, Y Zhang, X Shen, ...
Journal of Biological Chemistry 298 (4), 2022
The two faces of aldehyde oxidase: oxidative and reductive transformations of 5-nitroquinoline
EM Paragas, SC Humphreys, J Min, CA Joswig-Jones, JP Jones
Biochemical Pharmacology 145, 210-217, 2017
Tracking individual membrane proteins and their biochemistry: The power of direct observation
AO Barden, AS Goler, SC Humphreys, S Tabatabaei, M Lochner, ...
Neuropharmacology 98, 22-30, 2015
Considerations and recommendations for assessment of plasma protein binding and drug–drug interactions for siRNA therapeutics
SC Humphreys, JA Davis, S Iqbal, A Kamel, K Kulmatycki, Y Lao, X Liu, ...
Nucleic acids research 50 (11), 6020-6037, 2022
Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
SC Humphreys, MB Thayer, JM Lade, B Wu, K Sham, B Basiri, Y Hao, ...
Drug Metabolism and Disposition 47 (10), 1174-1182, 2019
Quantification of siRNA-antibody conjugates in biological matrices by triplex-forming oligonucleotide ELISA
SC Humphreys, MB Thayer, IDG Campuzano, C Netirojjanakul, BM Rock
nucleic acid therapeutics 29 (3), 161-166, 2019
Emerging siRNA design principles and consequences for biotransformation and disposition in drug development
SC Humphreys, MB Thayer, J Campbell, WLK Chen, D Adams, JM Lade, ...
Journal of Medicinal Chemistry 63 (12), 6407-6422, 2020
Introducing an in vitro liver stability assay capable of predicting the in vivo pharmacodynamic efficacy of siRNAs for IVIVC
B Basiri, F Xie, B Wu, SC Humphreys, JM Lade, MB Thayer, P Yamaguchi, ...
Molecular Therapy-Nucleic Acids 21, 725-736, 2020
POE Immunoassay: Plate-based oligonucleotide electro-chemiluminescent immunoassay for the quantification of nucleic acids in biological matrices
MB Thayer, SC Humphreys, KS Chung, JM Lade, KD Cook, BM Rock
Scientific reports 10 (1), 1-9, 2020
ecoAO: a simple system for the study of human aldehyde oxidases role in drug metabolism
EM Paragas, SC Humphreys, J Min, CA Joswig-Jones, S Leimkühler, ...
ACS omega 2 (8), 4820-4827, 2017
Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics
D Ramsden, DG Belair, S Agarwal, P Andersson, S Humphreys, ...
ALTEX-Alternatives to animal experimentation 39 (2), 273-296, 2022
Substrate Dependent Native Luminescence from Cytochromes P450 3A4, 2C9, and P450cam
C Barnaba, SC Humphreys, AO Barden, JP Jones, JA Brozik
The Journal of Physical Chemistry B 120 (12), 3038-3047, 2016
Prolonged cultured human hepatocytes as an in vitro experimental system for the evaluation of potency and duration of activity of RNA therapeutics: Demonstration of prolonged …
Q Yang, SC Humphreys, JM Lade, AP Li
Biochemical Pharmacology 189, 114374, 2021
Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation
AB Reed, BA Lanman, JR Holder, BH Yang, J Ma, SC Humphreys, ...
Bioorganic & Medicinal Chemistry Letters 30 (21), 127499, 2020
Industry perspective on the pharmacokinetic and ADME characterization of heterobifunctional protein degraders
LP Volak, HM Duevel, S Humphreys, D Nettleton, C Phipps, A Pike, ...
Drug metabolism and disposition, 2023
Industry Perspective on the Pharmacokinetic and Absorption, Distribution, Metabolism, and Excretion Characterization of Heterobifunctional Protein Degraders
LP Volak, HM Duevel, S Humphreys, D Nettleton, C Phipps, A Pike, ...
Drug Metabolism and Disposition 51 (7), 792-803, 2023
Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies
M Mock, AW Jacobitz, CJ Langmead, A Sudom, D Yoo, SC Humphreys, ...
MAbs 15 (1), 2256745, 2023
Microphysiological endothelial models to characterize subcutaneous drug absorption
GS Offeddu, JC Serrano, Z Wan, MA Bryniarski, SC Humphreys, SW Chen, ...
ALTEX-Alternatives to animal experimentation 40 (2), 299-313, 2023
Case study 12: roadmap to quantifying ago2-mediated siRNA metabolic activation kinetics
SC Humphreys, B Basiri, A Abbasi, BM Rock
Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, 825-841, 2021
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Články 1–20