|Keeping the eIF2 alpha kinase Gcn2 in check|
BA Castilho, R Shanmugam, RC Silva, R Ramesh, BM Himme, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1843 (9), 1948-1968, 2014
|Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells|
E Sattlegger, AG Hinnebusch
The EMBO Journal 19 (23), 6622-6633, 2000
|IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation|
CM Pereira, E Sattlegger, HY Jiang, BM Longo, CB Jaqueta, ...
Journal of Biological Chemistry 280 (31), 28316-28323, 2005
|cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2α kinase and histidyl-tRNA synthetase-related domains required for general amino …|
E Sattlegger, AG Hinnebusch, IB Barthelmess
Journal of Biological Chemistry 273 (32), 20404-20416, 1998
|Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2α kinase GCN2 during amino acid starvation|
E Sattlegger, AG Hinnebusch
Journal of Biological Chemistry 280 (16), 16514-16521, 2005
|YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed|
E Sattlegger, MJ Swanson, EA Ashcraft, JL Jennings, RA Fekete, AJ Link, ...
Journal of Biological Chemistry 279 (29), 29952-29962, 2004
|The WD protein Cpc2p is required for repression of Gcn4 protein activity in yeast in the absence of amino‐acid starvation|
B Hoffmann, HU Mösch, E Sattlegger, IB Barthelmess, A Hinnebusch, ...
Molecular microbiology 31 (3), 807-822, 1999
|The cpc-2 gene ofNeurospora crassa encodes a protein entirely composed of WD-repeat segments that is involved in general amino acid control and female fertility|
F Müller, D Krüger, E Sattlegger, B Hoffmann, P Ballario, M Kanaan, ...
Molecular and General Genetics MGG 248 (2), 162-173, 1995
|Evidence That Eukaryotic Translation Elongation Factor 1A (eEF1A) Binds the Gcn2 Protein C Terminus and Inhibits Gcn2 Activity*♦|
J Visweswaraiah, S Lageix, BA Castilho, L Izotova, TG Kinzy, ...
Journal of Biological Chemistry 286 (42), 36568-36579, 2011
|Biophysical characterization of Gir2, a highly acidic protein of Saccharomyces cerevisiae with anomalous electrophoretic behavior|
VS Alves, DC Pimenta, E Sattlegger, BA Castilho
Biochemical and biophysical research communications 314 (1), 229-234, 2004
|Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2|
E Sattlegger, JARG Barbosa, MCS Moraes, RM Martins, AG Hinnebusch, ...
Journal of Biological Chemistry 286 (12), 10341-10355, 2011
|Transcriptional defect of an inherited NKX2-5 haplotype comprising a SNP, a nonsynonymous and a synonymous mutation, associated with human congenital heart disease|
SM Reamon-Buettner, E Sattlegger, Y Ciribilli, A Inga, A Wessel, J Borlak
PLoS One 8 (12), e83295, 2013
|Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response|
RC Silva, E Sattlegger, BA Castilho
Journal of Cell Science 129 (24), 4521-4533, 2016
|Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2|
TD Cambiaghi, CM Pereira, R Shanmugam, M Bolech, RC Wek, ...
Biochemical and biophysical research communications 443 (2), 592-597, 2014
|Saccharomyces cerevisiae Rbg1 Protein and Its Binding Partner Gir2 Interact on Polyribosomes with Gcn1|
PK Wout, E Sattlegger, SM Sullivan, JR Maddock
Eukaryotic cell 8 (7), 1061-1071, 2009
|Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation|
J Visweswaraiah, SJ Lee, AG Hinnebusch, E Sattlegger
Journal of Biological Chemistry 287 (45), 37757-37768, 2012
|Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2|
SJ Lee, MJ Swanson, E Sattlegger
Biochemical Journal 466 (3), 547-559, 2015
|The Gcn2 regulator Yih1 interacts with the cyclin dependent kinase Cdc28 and promotes cell cycle progression through G2/M in budding yeast|
RC Silva, M Dautel, BM Di Genova, DC Amberg, BA Castilho, ...
PloS one 10 (7), e0131070, 2015
|Evidence that Yih1 resides in a complex with ribosomes|
T Waller, SJ Lee, E Sattlegger
The FEBS journal 279 (10), 1761-1776, 2012
|Yeast studies reveal moonlighting functions of the ancient actin cytoskeleton|
E Sattlegger, TA Chernova, NM Gogoi, IV Pillai, YO Chernoff, AL Munn
IUBMB life 66 (8), 538-545, 2014