Lysosome-targeting chimaeras for degradation of extracellular proteins SM Banik, K Pedram, S Wisnovsky, G Ahn, NM Riley, CR Bertozzi Nature 584 (7820), 291-297, 2020 | 678 | 2020 |
Targeting mitochondrial DNA with a platinum-based anticancer agent SP Wisnovsky, JJ Wilson, RJ Radford, MP Pereira, MR Chan, RR Laposa, ... Chemistry & biology 20 (11), 1323-1328, 2013 | 223 | 2013 |
Peptide-mediated delivery of chemical probes and therapeutics to mitochondria SR Jean, M Ahmed, EK Lei, SP Wisnovsky, SO Kelley Accounts of chemical research 49 (9), 1893-1902, 2016 | 215 | 2016 |
Molecular vehicles for mitochondrial chemical biology and drug delivery S Rin Jean, DV Tulumello, SP Wisnovsky, EK Lei, MP Pereira, SO Kelley ACS chemical biology 9 (2), 323-333, 2014 | 144 | 2014 |
Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes S Wisnovsky, SR Jean, S Liyanage, A Schimmer, SO Kelley Nature chemical biology 12 (7), 567-573, 2016 | 105 | 2016 |
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7 S Wisnovsky, L Möckl, SA Malaker, K Pedram, GT Hess, NM Riley, ... Proceedings of the National Academy of Sciences 118 (5), e2015024118, 2021 | 100 | 2021 |
Mitochondrial chemical biology: new probes elucidate the secrets of the powerhouse of the cell S Wisnovsky, EK Lei, SR Jean, SO Kelley Cell chemical biology 23 (8), 917-927, 2016 | 96 | 2016 |
Bump-and-hole engineering identifies specific substrates of glycosyltransferases in living cells B Schumann, SA Malaker, SP Wisnovsky, MF Debets, AJ Agbay, ... Molecular cell 78 (5), 824-834. e15, 2020 | 90 | 2020 |
Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation MF Debets, OY Tastan, SP Wisnovsky, SA Malaker, N Angelis, ... Proceedings of the National Academy of Sciences 117 (41), 25293-25301, 2020 | 62 | 2020 |
Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism R Mourtada, SB Fonseca, SP Wisnovsky, MP Pereira, X Wang, R Hurren, ... PloS one 8 (4), e60253, 2013 | 42 | 2013 |
Design of a mucin-selective protease for targeted degradation of cancer-associated mucins K Pedram, DJ Shon, GS Tender, NR Mantuano, JJ Northey, KJ Metcalf, ... Nature biotechnology 42 (4), 597-607, 2024 | 33 | 2024 |
Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth E Scott, K Hodgson, B Calle, H Turner, K Cheung, A Bermudez, ... Oncogene 42 (12), 926-937, 2023 | 32 | 2023 |
DNA polymerase θ increases mutational rates in mitochondrial DNA S Wisnovsky, T Sack, DJ Pagliarini, RR Laposa, SO Kelley ACS chemical biology 13 (4), 900-908, 2018 | 32 | 2018 |
Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras G Ahn, NM Riley, RA Kamber, S Wisnovsky, S Moncayo von Hase, ... Science 382 (6668), eadf6249, 2023 | 31 | 2023 |
Reading the glyco-code: New approaches to studying protein–carbohydrate interactions S Wisnovsky, CR Bertozzi Current opinion in structural biology 75, 102395, 2022 | 29 | 2022 |
Mitochondria-penetrating peptides conjugated to desferrioxamine as chelators for mitochondrial labile iron RYP Alta, HA Vitorino, D Goswami, CW Liria, SP Wisnovsky, SO Kelley, ... PloS one 12 (2), e0171729, 2017 | 29 | 2017 |
Lysosome targeting chimeras (LYTACs) for the degradation of secreted and membrane proteins S Banik, K Pedram, S Wisnovsky, N Riley, C Bertozzi | 28 | 2019 |
MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint BAH Smith, A Deutzmann, KM Correa, CS Delaveris, R Dhanasekaran, ... Proceedings of the National Academy of Sciences 120 (11), e2215376120, 2023 | 27 | 2023 |
The 5′ binding MID domain of human Argonaute2 tolerates chemically modified nucleotide analogues GF Deleavey, F Frank, M Hassler, S Wisnovsky, B Nagar, MJ Damha Nucleic acid therapeutics 23 (1), 81-87, 2013 | 18 | 2013 |
Antibody-lectin chimeras for glyco-immune checkpoint blockade JC Stark, MA Gray, S Wisnovsky, I Ibarlucea-Benitez, NM Riley, MK Ribi, ... BioRxiv, 2022.10. 26.513931, 2022 | 9 | 2022 |