| BODIL: a molecular modeling environment for structure-function analysis and drug design JV Lehtonen, DJ Still, V Rantanen, J Ekholm, D Björklund, Z Iftikhar, ... Journal of computer-aided molecular design 18, 401-419, 2004 | 245 | 2004 |
| Glucuronidation converts clopidogrel to a strong time‐dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug–drug interactions A Tornio, AM Filppula, O Kailari, M Neuvonen, TH Nyrönen, T Tapaninen, ... Clinical Pharmacology & Therapeutics 96 (4), 498-507, 2014 | 135 | 2014 |
| GA4GH: International policies and standards for data sharing across genomic research and healthcare HL Rehm, AJH Page, L Smith, JB Adams, G Alterovitz, LJ Babb, ... Cell genomics 1 (2), 2021 | 130 | 2021 |
| An in silico approach to discovering novel inhibitors of human sirtuin type 2 AJ Tervo, S Kyrylenko, P Niskanen, A Salminen, J Leppänen, TH Nyrönen, ... Journal of medicinal chemistry 47 (25), 6292-6298, 2004 | 129 | 2004 |
| Leveraging European infrastructures to access 1 million human genomes by 2022 G Saunders, M Baudis, R Becker, S Beltran, C Béroud, E Birney, ... Nature Reviews Genetics 20 (11), 693-701, 2019 | 91 | 2019 |
| Molecular mechanism for agonist-promoted α2A-adrenoceptor activation by norepinephrine and epinephrine T Nyrönen, M Pihlavisto, JM Peltonen, AM Hoffrén, M Varis, T Salminen, ... Molecular Pharmacology 59 (5), 1343-1354, 2001 | 83 | 2001 |
| Bioinformatics training: a review of challenges, actions and support requirements MV Schneider, J Watson, T Attwood, K Rother, A Budd, J McDowall, A Via, ... Briefings in bioinformatics 11 (6), 544-551, 2010 | 79 | 2010 |
| Best practices in bioinformatics training for life scientists A Via, T Blicher, E Bongcam-Rudloff, MD Brazas, C Brooksbank, A Budd, ... Briefings in bioinformatics 14 (5), 528-537, 2013 | 73 | 2013 |
| Federated identity management for research collaborations D Broeder, R Wartel, B Jones, P Kershaw, D Kelsey, S Lüders, A Lyall, ... | 64 | 2012 |
| Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines H Xhaard, VV Rantanen, T Nyrönen, MS Johnson Journal of medicinal chemistry 49 (5), 1706-1719, 2006 | 63 | 2006 |
| Three-dimensional structure− activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain AA Söderholm, PT Lehtovuori, TH Nyrönen Journal of medicinal chemistry 48 (4), 917-925, 2005 | 60 | 2005 |
| A structure-activity relationship study of catechol-O-methyltransferase inhibitors combining molecular docking and 3D QSAR methods AJ Tervo, TH Nyrönen, T Rönkkö, A Poso Journal of Computer-Aided Molecular Design 17, 797-810, 2003 | 59 | 2003 |
| The bio.tools registry of software tools and data resources for the life sciences J Ison, H Ienasescu, P Chmura, E Rydza, H Ménager, M Kalaš, ... Genome biology 20, 1-4, 2019 | 54 | 2019 |
| Three-dimensional models of α2A-adrenergic receptor complexes provide a structural explanation for ligand binding T Salminen, M Varis, T Nyrönen, M Pihlavisto, AM Hoffrén, T Lönnberg, ... Journal of Biological Chemistry 274 (33), 23405-23413, 1999 | 53 | 1999 |
| BRUTUS: optimization of a grid-based similarity function for rigid-body molecular superposition. 1. Alignment and virtual screening applications AJ Tervo, T Rönkkö, TH Nyrönen, A Poso Journal of medicinal chemistry 48 (12), 4076-4086, 2005 | 52 | 2005 |
| Comparing the quality and predictiveness between 3D QSAR models obtained from manual and automated alignment AJ Tervo, TH Nyrönen, T Rönkkö, A Poso Journal of chemical information and computer sciences 44 (3), 807-816, 2004 | 50 | 2004 |
| Molecular mechanisms of ligand–receptor interactions in transmembrane domain V of the α2A‐adrenoceptor JM Peltonen, T Nyrönen, S Wurster, M Pihlavisto, AM Hoffrén, ... British journal of pharmacology 140 (2), 347-358, 2003 | 49 | 2003 |
| Model structures of α-2 adrenoceptors in complex with automatically docked antagonist ligands raise the possibility of interactions dissimilar from agonist ligands H Xhaard, T Nyrönen, VV Rantanen, JO Ruuskanen, J Laurila, ... Journal of structural biology 150 (2), 126-143, 2005 | 46 | 2005 |
| The Data Use Ontology to streamline responsible access to human biomedical datasets J Lawson, MN Cabili, G Kerry, T Boughtwood, A Thorogood, P Alper, ... Cell Genomics 1 (2), 2021 | 40 | 2021 |
| “RKKH” Peptides from the Snake Venom Metalloproteinase ofBothrops jararaca Bind Near the Metal Ion-dependent Adhesion Site of the Human Integrin α2 I-domain O Pentikäinen, AM Hoffrén, J Ivaska, J Käpylä, T Nyrönen, J Heino, ... Journal of Biological Chemistry 274 (44), 31493-31505, 1999 | 40 | 1999 |
Olli PentikäinenProfessor of Medicinal ChemistryVerified email at utu.fi
