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Ralph Hruban
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PD-1 blockade in tumors with mismatch-repair deficiency
DT Le, JN Uram, H Wang, BR Bartlett, H Kemberling, AD Eyring, ...
New England Journal of Medicine 372 (26), 2509-2520, 2015
73622015
WHO classification of tumours of the digestive system.
FT Bosman, F Carneiro, RH Hruban, ND Theise
WHO classification of tumours of the digestive system., 2010
59612010
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
S Jones, X Zhang, DW Parsons, JCH Lin, RJ Leary, P Angenendt, ...
science 321 (5897), 1801-1806, 2008
41792008
Detection of circulating tumor DNA in early-and late-stage human malignancies
C Bettegowda, M Sausen, RJ Leary, I Kinde, Y Wang, N Agrawal, ...
Science translational medicine 6 (224), 224ra24-224ra24, 2014
36672014
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
KP Olive, MA Jacobetz, CJ Davidson, A Gopinathan, D McIntyre, ...
Science 324 (5933), 1457-1461, 2009
31422009
DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
SA Hahn, M Schutte, ATM Shamsul Hoque, CA Moskaluk, LT Da Costa, ...
Science 271 (5247), 350-353, 1996
31191996
WHO classification of tumours of female reproductive organs
RH Young
Kurman RJ Carcangiu ML Herrington CS Young RH Monodermal teratomas and …, 2014
29632014
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
S Yachida, S Jones, I Bozic, T Antal, R Leary, B Fu, M Kamiyama, ...
Nature 467 (7319), 1114-1117, 2010
25652010
Pancreatic cancer
A Vincent, J Herman, R Schulick, RH Hruban, M Goggins
The lancet 378 (9791), 607-620, 2011
24872011
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
SR Hingorani, EF Petricoin III, A Maitra, V Rajapakse, C King, ...
Cancer cell 4 (6), 437-450, 2003
24402003
Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes.
CJ Yeo, JL Cameron, TA Sohn, KD Lillemoe, HA Pitt, MA Talamini, ...
Annals of surgery 226 (3), 248, 1997
23091997
Genomic analyses identify molecular subtypes of pancreatic cancer
P Bailey, DK Chang, K Nones, AL Johns, AM Patch, MC Gingras, ...
Nature 531 (7592), 47-52, 2016
22982016
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
SR Hingorani, L Wang, AS Multani, C Combs, TB Deramaudt, RH Hruban, ...
Cancer cell 7 (5), 469-483, 2005
22382005
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
GM DeNicola, FA Karreth, TJ Humpton, A Gopinathan, C Wei, K Frese, ...
Nature 475 (7354), 106-109, 2011
2219*2011
Whole genomes redefine the mutational landscape of pancreatic cancer
N Waddell, M Pajic, AM Patch, DK Chang, KS Kassahn, P Bailey, ...
Nature 518 (7540), 495-501, 2015
20732015
A draft map of the human proteome
MS Kim, SM Pinto, D Getnet, RS Nirujogi, SS Manda, R Chaerkady, ...
Nature 509 (7502), 575-581, 2014
20582014
Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy
GM Felker, RE Thompson, JM Hare, RH Hruban, DE Clemetson, ...
New England Journal of Medicine 342 (15), 1077-1084, 2000
19202000
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
AV Biankin, N Waddell, KS Kassahn, MC Gingras, LB Muthuswamy, ...
Nature 491 (7424), 399-405, 2012
18662012
Gene expression profiles in normal and cancer cells
L Zhang, W Zhou, VE Velculescu, SE Kern, RH Hruban, SR Hamilton, ...
Science 276 (5316), 1268-1272, 1997
18491997
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
N Agrawal, MJ Frederick, CR Pickering, C Bettegowda, K Chang, RJ Li, ...
Science 333 (6046), 1154-1157, 2011
17892011
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