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Ralph Hruban
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PD-1 blockade in tumors with mismatch-repair deficiency
DT Le, JN Uram, H Wang, BR Bartlett, H Kemberling, AD Eyring, ...
New England Journal of Medicine 372 (26), 2509-2520, 2015
84802015
WHO classification of tumours of the digestive system.
FT Bosman, F Carneiro, RH Hruban, ND Theise
WHO classification of tumours of the digestive system., 2010
64422010
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
S Jones, X Zhang, DW Parsons, JCH Lin, RJ Leary, P Angenendt, ...
science 321 (5897), 1801-1806, 2008
43952008
Detection of circulating tumor DNA in early-and late-stage human malignancies
C Bettegowda, M Sausen, RJ Leary, I Kinde, Y Wang, N Agrawal, ...
Science translational medicine 6 (224), 224ra24-224ra24, 2014
41672014
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
KP Olive, MA Jacobetz, CJ Davidson, A Gopinathan, D McIntyre, ...
Science 324 (5933), 1457-1461, 2009
33432009
DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
SA Hahn, M Schutte, ATM Shamsul Hoque, CA Moskaluk, LT Da Costa, ...
Science 271 (5247), 350-353, 1996
31781996
Pancreatic cancer
A Vincent, J Herman, R Schulick, RH Hruban, M Goggins
The lancet 378 (9791), 607-620, 2011
27912011
Genomic analyses identify molecular subtypes of pancreatic cancer
P Bailey, DK Chang, K Nones, AL Johns, AM Patch, MC Gingras, ...
Nature 531 (7592), 47-52, 2016
27602016
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
S Yachida, S Jones, I Bozic, T Antal, R Leary, B Fu, M Kamiyama, ...
Nature 467 (7319), 1114-1117, 2010
27462010
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
SR Hingorani, EF Petricoin, A Maitra, V Rajapakse, C King, MA Jacobetz, ...
Cancer cell 4 (6), 437-450, 2003
26242003
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
GM DeNicola, FA Karreth, TJ Humpton, A Gopinathan, C Wei, K Frese, ...
Nature 475 (7354), 106-109, 2011
2493*2011
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
SR Hingorani, L Wang, AS Multani, C Combs, TB Deramaudt, RH Hruban, ...
Cancer cell 7 (5), 469-483, 2005
24612005
Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes.
CJ Yeo, JL Cameron, TA Sohn, KD Lillemoe, HA Pitt, MA Talamini, ...
Annals of surgery 226 (3), 248, 1997
23621997
Whole genomes redefine the mutational landscape of pancreatic cancer
N Waddell, M Pajic, AM Patch, DK Chang, KS Kassahn, P Bailey, ...
Nature 518 (7540), 495-501, 2015
23582015
A draft map of the human proteome
MS Kim, SM Pinto, D Getnet, RS Nirujogi, SS Manda, R Chaerkady, ...
Nature 509 (7502), 575-581, 2014
22772014
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
AV Biankin, N Waddell, KS Kassahn, MC Gingras, LB Muthuswamy, ...
Nature 491 (7424), 399-405, 2012
20472012
Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy
GM Felker, RE Thompson, JM Hare, RH Hruban, DE Clemetson, ...
New England Journal of Medicine 342 (15), 1077-1084, 2000
20182000
Detection and localization of surgically resectable cancers with a multi-analyte blood test
JD Cohen, L Li, Y Wang, C Thoburn, B Afsari, L Danilova, C Douville, ...
Science 359 (6378), 926-930, 2018
19772018
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
N Agrawal, MJ Frederick, CR Pickering, C Bettegowda, K Chang, RJ Li, ...
Science 333 (6046), 1154-1157, 2011
18942011
Gene expression profiles in normal and cancer cells
L Zhang, W Zhou, VE Velculescu, SE Kern, RH Hruban, SR Hamilton, ...
Science 276 (5316), 1268-1272, 1997
18911997
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