Lyn-Marie Birkholtz
Lyn-Marie Birkholtz
Verified email at up.ac.za
TitleCited byYear
Polyamine homeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities
LM Birkholtz, M Williams, J Niemand, A Louw, L Persson, O Heby
Biochemical Journal 438 (2), 229-244, 2011
892011
Heterologous expression of plasmodial proteins for structural studies and functional annotation
LM Birkholtz, G Blatch, TL Coetzer, HC Hoppe, E Human, EJ Morris, ...
Malaria journal 7 (1), 197, 2008
832008
Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome …
AC van Brummelen, KL Olszewski, D Wilinski, M Llinás, AI Louw, ...
Journal of Biological Chemistry 284 (7), 4635-4646, 2009
802009
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
T Paquet, C Le Manach, DG Cabrera, Y Younis, PP Henrich, TS Abraham, ...
Science translational medicine 9 (387), eaad9735, 2017
672017
Discovery of novel alkylated (bis) urea and (bis) thiourea polyamine analogues with potent antimalarial activities
BK Verlinden, J Niemand, J Snyman, SK Sharma, RJ Beattie, PM Woster, ...
Journal of medicinal chemistry 54 (19), 6624-6633, 2011
672011
Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination
J Reader, M Botha, A Theron, SB Lauterbach, C Rossouw, D Engelbrecht, ...
Malaria journal 14 (1), 213, 2015
562015
Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain …
LM Birkholtz, C Wrenger, F Joubert, GA Wells, RD Walter, AI Louw
Biochemical Journal 377 (2), 439-448, 2004
562004
Functional consequences of perturbing polyamine metabolism in the malaria parasite, Plasmodium falciparum
K Clark, J Niemand, S Reeksting, S Smit, AC Van Brummelen, M Williams, ...
Amino acids 38 (2), 633-644, 2010
392010
Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling
GA Wells, LM Birkholtz, F Joubert, RD Walter, AI Louw
Journal of Molecular Graphics and Modelling 24 (4), 307-318, 2006
382006
Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
JVW Becker, L Mtwisha, BG Crampton, S Stoychev, AC van Brummelen, ...
BMC genomics 11 (1), 235, 2010
352010
Antimalarial drug discovery: in silico structural biology and rational drug design
TAP De Beer, GA Wells, PB Burger, F Joubert, E Marechal, L Birkholtz, ...
Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2009
332009
Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?
LM Birkholtz, O Bastien, G Wells, D Grando, F Joubert, V Kasam, ...
Malaria journal 5 (1), 110, 2006
322006
Comparative properties of a three‐dimensional model of Plasmodium falciparum ornithine decarboxylase
L Birkholtz, F Joubert, AWH Neitz, AI Louw
Proteins: Structure, Function, and Bioinformatics 50 (3), 464-473, 2003
322003
Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase
PB Burger, LM Birkholtz, F Joubert, N Haider, RD Walter, AI Louw
Bioorganic & medicinal chemistry 15 (4), 1628-1637, 2007
292007
Exploring functional genomics for drug target and therapeutics discovery in Plasmodia
L Birkholtz, AC Van Brummelen, K Clark, J Niemand, E Maréchal, ...
Acta tropica 105 (2), 113-123, 2008
272008
Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life cycle
C Le Manach, AT Nchinda, T Paquet, D Gonzàlez Cabrera, Y Younis, ...
Journal of medicinal chemistry 59 (21), 9890-9905, 2016
262016
Transcriptional responses of Plasmodium falciparum to α-difluoromethylornithine-induced polyamine depletion
K Clark, M Dhoogra, AI Louw, LM Birkholtz
Biological chemistry 389 (2), 111-125, 2008
262008
Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters
FJ Smit, RA van Biljon, LM Birkholtz, DND David
European journal of medicinal chemistry 90, 33-44, 2015
252015
Polyamine uptake by the intraerythrocytic malaria parasite, Plasmodium falciparum
J Niemand, AI Louw, L Birkholtz, K Kirk
International journal for parasitology 42 (10), 921-929, 2012
232012
Resisting resistance: is there a solution for malaria?
BK Verlinden, A Louw, LM Birkholtz
Expert opinion on drug discovery 11 (4), 395-406, 2016
222016
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