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Rui Yang
Rui Yang
Verified email at duke.edu
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Year
Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas
PJ Killela, CJ Pirozzi, P Healy, ZJ Reitman, E Lipp, BA Rasheed, R Yang, ...
Oncotarget 5 (6), 1515, 2014
2932014
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas
L Zhang, LH Chen, H Wan, R Yang, Z Wang, J Feng, S Yang, S Jones, ...
Nature genetics 46 (7), 726-730, 2014
1802014
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas
G Jin, ZJ Reitman, CG Duncan, I Spasojevic, DM Gooden, BA Rasheed, ...
Cancer research 73 (2), 496-501, 2013
1532013
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma
BH Diplas, X He, JA Brosnan-Cashman, H Liu, LH Chen, Z Wang, ...
Nature communications 9 (1), 2087, 2018
1522018
Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation
R Yang, LH Chen, LJ Hansen, AB Carpenter, CJ Moure, H Liu, CJ Pirozzi, ...
Cancer research 77 (22), 6097-6108, 2017
512017
Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities
MS Waitkus, CJ Pirozzi, CJ Moure, BH Diplas, LJ Hansen, AB Carpenter, ...
Cancer research 78 (1), 36-50, 2018
392018
MTAP loss promotes stemness in glioblastoma and confers unique susceptibility to purine starvation
LJ Hansen, R Sun, R Yang, SX Singh, LH Chen, CJ Pirozzi, CJ Moure, ...
Cancer research 79 (13), 3383-3394, 2019
372019
Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas
BH Diplas, H Liu, R Yang, LJ Hansen, AL Zachem, F Zhao, DD Bigner, ...
Neuro-oncology 21 (4), 440-450, 2019
342019
Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors
C Xu, X Liu, Y Geng, Q Bai, C Pan, Y Sun, X Chen, H Yu, Y Wu, P Zhang, ...
Oncotarget 8 (44), 76644, 2017
292017
Humanized mouse model of Cooley's anemia
Y Huo, SC McConnell, SR Liu, R Yang, TT Zhang, CW Sun, LC Wu, ...
Journal of biological chemistry 284 (8), 4889-4896, 2009
282009
CRISPR editing of mutant IDH1 R132H induces a CpG methylation-low state in patient-derived glioma models of G-CIMP
CJ Moure, BH Diplas, LH Chen, R Yang, CJ Pirozzi, Z Wang, I Spasojevic, ...
Molecular Cancer Research 17 (10), 2042-2050, 2019
202019
Functional analysis of a gene encoding a chlorotoxin-like peptide derived from scorpion toxin
R Yang, F Peng, H Liu, Z Cao, W LI, X Mao, D Jiang
Chinese Journal of Biochemistry and Molecular Biology, 19-23, 2005
162005
Humanized mouse models of Cooley's anemia: correct fetal‐to‐adult hemoglobin switching, disease onset, and disease pathology
Y Huo, SC McConnell, S Liu, T Zhang, R Yang, J Ren, TM Ryan
Annals of the New York Academy of Sciences 1202 (1), 45-51, 2010
152010
MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization
LJ Hansen, R Yang, K Roso, W Wang, L Chen, Q Yang, CJ Pirozzi, Y He
Scientific Reports 12 (1), 4183, 2022
122022
Purine synthesis inhibitor L-Alanosine impairs mitochondrial function and stemness of brain tumor initiating cells
SX Singh, R Yang, K Roso, LJ Hansen, C Du, LH Chen, PK Greer, ...
Biomedicines 10 (4), 751, 2022
62022
Epigenetic regulation of fanconi anemia genes implicates PRMT5 blockage as a strategy for tumor chemosensitization
C Du, SW Li, SX Singh, K Roso, MA Sun, CJ Pirozzi, R Yang, JL Li, Y He
Molecular Cancer Research 19 (12), 2046-2056, 2022
42022
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
H Yan, PJ Killela, ZJ Reitman, Y Jiao, C Bettegowda, N Agrawal, ...
Neuro-Oncology 16 (suppl_3), iii5-iii6, 2014
32014
Repurposing clemastine to target glioblastoma cell stemness
MA Sun, R Yang, H Liu, W Wang, X Song, B Hu, N Reynolds, K Roso, ...
Cancers 15 (18), 4619, 2023
12023
Inhibiting adenine synthesis attenuates glioblastoma cell stemness and temozolomide resistance
SX Singh, R Yang, K Roso, LJ Hansen, C Du, LH Chen, PK Greer, ...
bioRxiv, 2021.06. 21.449341, 2021
12021
Distribution and vulnerability of transcriptional outputs across the genome in Myc-amplified medulloblastoma cells
R Yang, W Wang, M Dong, K Roso, P Greer, X Bao, CJ Pirozzi, DD Bigner, ...
bioRxiv, 2021.06. 07.447394, 2021
12021
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