Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas PJ Killela, CJ Pirozzi, P Healy, ZJ Reitman, E Lipp, BA Rasheed, R Yang, ... Oncotarget 5 (6), 1515, 2014 | 293 | 2014 |
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas L Zhang, LH Chen, H Wan, R Yang, Z Wang, J Feng, S Yang, S Jones, ... Nature genetics 46 (7), 726-730, 2014 | 180 | 2014 |
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas G Jin, ZJ Reitman, CG Duncan, I Spasojevic, DM Gooden, BA Rasheed, ... Cancer research 73 (2), 496-501, 2013 | 153 | 2013 |
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma BH Diplas, X He, JA Brosnan-Cashman, H Liu, LH Chen, Z Wang, ... Nature communications 9 (1), 2087, 2018 | 152 | 2018 |
Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation R Yang, LH Chen, LJ Hansen, AB Carpenter, CJ Moure, H Liu, CJ Pirozzi, ... Cancer research 77 (22), 6097-6108, 2017 | 51 | 2017 |
Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities MS Waitkus, CJ Pirozzi, CJ Moure, BH Diplas, LJ Hansen, AB Carpenter, ... Cancer research 78 (1), 36-50, 2018 | 39 | 2018 |
MTAP loss promotes stemness in glioblastoma and confers unique susceptibility to purine starvation LJ Hansen, R Sun, R Yang, SX Singh, LH Chen, CJ Pirozzi, CJ Moure, ... Cancer research 79 (13), 3383-3394, 2019 | 37 | 2019 |
Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas BH Diplas, H Liu, R Yang, LJ Hansen, AL Zachem, F Zhao, DD Bigner, ... Neuro-oncology 21 (4), 440-450, 2019 | 34 | 2019 |
Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors C Xu, X Liu, Y Geng, Q Bai, C Pan, Y Sun, X Chen, H Yu, Y Wu, P Zhang, ... Oncotarget 8 (44), 76644, 2017 | 29 | 2017 |
Humanized mouse model of Cooley's anemia Y Huo, SC McConnell, SR Liu, R Yang, TT Zhang, CW Sun, LC Wu, ... Journal of biological chemistry 284 (8), 4889-4896, 2009 | 28 | 2009 |
CRISPR editing of mutant IDH1 R132H induces a CpG methylation-low state in patient-derived glioma models of G-CIMP CJ Moure, BH Diplas, LH Chen, R Yang, CJ Pirozzi, Z Wang, I Spasojevic, ... Molecular Cancer Research 17 (10), 2042-2050, 2019 | 20 | 2019 |
Functional analysis of a gene encoding a chlorotoxin-like peptide derived from scorpion toxin R Yang, F Peng, H Liu, Z Cao, W LI, X Mao, D Jiang Chinese Journal of Biochemistry and Molecular Biology, 19-23, 2005 | 16 | 2005 |
Humanized mouse models of Cooley's anemia: correct fetal‐to‐adult hemoglobin switching, disease onset, and disease pathology Y Huo, SC McConnell, S Liu, T Zhang, R Yang, J Ren, TM Ryan Annals of the New York Academy of Sciences 1202 (1), 45-51, 2010 | 15 | 2010 |
MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization LJ Hansen, R Yang, K Roso, W Wang, L Chen, Q Yang, CJ Pirozzi, Y He Scientific Reports 12 (1), 4183, 2022 | 12 | 2022 |
Purine synthesis inhibitor L-Alanosine impairs mitochondrial function and stemness of brain tumor initiating cells SX Singh, R Yang, K Roso, LJ Hansen, C Du, LH Chen, PK Greer, ... Biomedicines 10 (4), 751, 2022 | 6 | 2022 |
Epigenetic regulation of fanconi anemia genes implicates PRMT5 blockage as a strategy for tumor chemosensitization C Du, SW Li, SX Singh, K Roso, MA Sun, CJ Pirozzi, R Yang, JL Li, Y He Molecular Cancer Research 19 (12), 2046-2056, 2022 | 4 | 2022 |
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal H Yan, PJ Killela, ZJ Reitman, Y Jiao, C Bettegowda, N Agrawal, ... Neuro-Oncology 16 (suppl_3), iii5-iii6, 2014 | 3 | 2014 |
Repurposing clemastine to target glioblastoma cell stemness MA Sun, R Yang, H Liu, W Wang, X Song, B Hu, N Reynolds, K Roso, ... Cancers 15 (18), 4619, 2023 | 1 | 2023 |
Inhibiting adenine synthesis attenuates glioblastoma cell stemness and temozolomide resistance SX Singh, R Yang, K Roso, LJ Hansen, C Du, LH Chen, PK Greer, ... bioRxiv, 2021.06. 21.449341, 2021 | 1 | 2021 |
Distribution and vulnerability of transcriptional outputs across the genome in Myc-amplified medulloblastoma cells R Yang, W Wang, M Dong, K Roso, P Greer, X Bao, CJ Pirozzi, DD Bigner, ... bioRxiv, 2021.06. 07.447394, 2021 | 1 | 2021 |