Pavlina Rezacova
Pavlina Rezacova
Head of Structural Biology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
E-mailová adresa ověřena na: uochb.cas.cz
Název
Citace
Citace
Rok
From nonpeptide toward noncarbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease
P Cígler, M Kožíšek, P Řezáčová, J Brynda, Z Otwinowski, J Pokorná, ...
Proceedings of the National Academy of Sciences 102 (43), 15394-15399, 2005
2672005
Link between a novel human γD-crystallin allele and a unique cataract phenotype explained by protein crystallography
S Kmoch, J Brynda, B Asfaw, K Bezouška, P Novák, P Řezáčová, ...
Human molecular genetics 9 (12), 1779-1786, 2000
1882000
Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes
P Rezacova, J Pokorná, J Brynda, M Kozisek, P Cigler, M Lepsik, ...
Journal of medicinal chemistry 52 (22), 7132-7141, 2009
1192009
A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation
J Chmelar, CJ Oliveira, P Rezacova, I Francischetti, Z Kovarova, G Pejler, ...
Blood 117 (2), 736-744, 2011
1162011
Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel
T Koudelakova, R Chaloupkova, J Brezovsky, Z Prokop, E Sebestova, ...
Angewandte Chemie 125 (7), 2013-2017, 2013
1132013
Current and novel inhibitors of HIV protease
J Pokorná, L Machala, P Řezáčová, J Konvalinka
Viruses 1 (3), 1209-1239, 2009
1012009
Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance
M Kožíšek, P Cígler, M Lepšík, J Fanfrlík, P Řezáčová, J Brynda, ...
Journal of medicinal chemistry 51 (15), 4839-4843, 2008
912008
Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants
M Kožíšek, J Bray, P Řezáčová, K Šašková, J Brynda, J Pokorná, ...
Journal of molecular biology 374 (4), 1005-1016, 2007
862007
Carborane‐based carbonic anhydrase inhibitors
J Brynda, P Mader, V Šícha, M Fábry, K Poncová, M Bakardiev, B Grüner, ...
Angewandte Chemie 125 (51), 14005-14008, 2013
662013
Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata
J Salát, GC Paesen, P Řezáčová, M Kotsyfakis, Z Kovářová, M Šanda, ...
Biochemical Journal 429 (1), 103-112, 2010
612010
Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni
A Jílková, P Řezáčová, M Lepšík, M Horn, J Váchová, J Fanfrlík, J Brynda, ...
Journal of Biological Chemistry 286 (41), 35770-35781, 2011
592011
Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir
KG Šašková, M Kožíšek, P Řezáčová, J Brynda, T Yashina, RM Kagan, ...
Journal of virology 83 (17), 8810-8818, 2009
522009
Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region
M Kožíšek, KG Šašková, P Řezáčová, J Brynda, NM van Maarseveen, ...
Journal of virology 82 (12), 5869-5878, 2008
492008
Engineering a de novo transport tunnel
J Brezovsky, P Babkova, O Degtjarik, A Fortova, A Gora, I Iermak, ...
ACS Catalysis 6 (11), 7597-7610, 2016
442016
Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold
J Schimer, P Cígler, J Veselý, K Grantz Šašková, M Lepsik, J Brynda, ...
Journal of medicinal chemistry 55 (22), 10130-10135, 2012
412012
Thermodynamic and structural analysis of HIV protease resistance to darunavir–analysis of heavily mutated patient‐derived HIV‐1 proteases
M Kožíšek, M Lepšík, K Grantz Šašková, J Brynda, J Konvalinka, ...
The FEBS journal 281 (7), 1834-1847, 2014
352014
Mutations in HIV-1 gag and pol compensate for the loss of viral fitness caused by a highly mutated protease
M Kožíšek, S Henke, KG Šašková, GB Jacobs, A Schuch, B Buchholz, ...
Antimicrobial agents and chemotherapy 56 (8), 4320-4330, 2012
352012
Crystal structure and putative function of small Toprim domain‐containing protein from Bacillus stearothermophilus
P Řezáčová, D Borek, SF Moy, A Joachimiak, Z Otwinowski
Proteins: Structure, Function, and Bioinformatics 70 (2), 311-319, 2008
342008
Structural basis of HIV-1 and HIV-2 protease inhibition by a monoclonal antibody
P Rezacova, J Lescar, J Brynda, M Fabry, M Horejsi, J Sedlacek, ...
Structure 9 (10), 887-895, 2001
332001
Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif
P Tesina, K Čermáková, M Hořejší, K Procházková, M Fábry, S Sharma, ...
Nature communications 6 (1), 1-14, 2015
322015
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Články 1–20