john alexander
john alexander
Cancer Bioinformatician, Institute of Cancer Research
E-mailová adresa ověřena na: - Domovská stránka
Clinical BRCA1/2 Reversion Analysis Identifies Hotspot Mutations and Predicted Neoantigens Associated with Therapy Resistance
SJ Pettitt, JR Frankum, M Punta, S Lise, J Alexander, Y Chen, TA Yap, ...
Cancer discovery 10 (10), 1475-1488, 2020
Modelling mutational landscapes of human cancers in vitro
M Olivier, A Weninger, M Ardin, H Huskova, X Castells, MP Vallée, ...
Scientific reports 4 (1), 4482, 2014
Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions
O Thompson, F von Meyenn, Z Hewitt, J Alexander, A Wood, ...
Nature communications 11 (1), 1528, 2020
17q21. 31 duplication causes prominent tau-related dementia with increased MAPT expression
K Le Guennec, O Quenez, G Nicolas, D Wallon, S Rousseau, AC Richard, ...
Molecular Psychiatry 22 (8), 1119-1125, 2017
Meta-analysis of Tourette Syndrome and Attention Deficit Hyperactivity Disorder provides support for a shared genetic basis
F Tsetsos, SS Padmanabhuni, J Alexander, I Karagiannidis, M Tsifintaris, ...
Frontiers in Neuroscience, 2016
Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
U Jungwirth, A van Weverwijk, RJ Evans, L Jenkins, D Vicente, ...
Nature Communications 12 (1), 3516, 2021
Targeted re-sequencing approach of candidate genes implicates rare potentially functional variants in Tourette syndrome etiology
J Alexander, H Potamianou, J Xing, L Deng, I Karagiannidis, F Tsetsos, ...
Frontiers in neuroscience 10, 428, 2016
TS-EUROTRAIN: a European-wide investigation and training network on the etiology and pathophysiology of Gilles de la Tourette syndrome
NJ Forde, AS Kanaan, J Widomska, SS Padmanabhuni, E Nespoli, ...
Frontiers in neuroscience 10, 384, 2016
Predicting the clinical outcome of oral potentially malignant disorders using transcriptomic-based molecular pathology
HP Sathasivam, R Kist, P Sloan, P Thomson, M Nugent, J Alexander, ...
British Journal of Cancer 125 (3), 413-421, 2021
Variant Ranker: a web-tool to rank genomic data according to functional significance
J Alexander, D Mantzaris, M Georgitsi, P Drineas, P Paschou
BMC bioinformatics 18, 1-9, 2017
Familial early-onset dementia with complex neuropathologic phenotype and genomic background
J Alexander, O Kalev, S Mehrabian, L Traykov, M Raycheva, D Kanakis, ...
Neurobiology of Aging 42, 199-204, 2016
The genetics of Gilles de la Tourette syndrome: a common aetiological basis with comorbid disorders?
I Karagiannidis, F Tsetsos, SS Padmanabhuni, J Alexander, M Georgitsi, ...
Current Behavioral Neuroscience Reports 3, 218-231, 2016
ELTD1 activation induces an endothelial-EMT transition to a myofibroblast phenotype
H Sheldon, J Alexander, E Bridges, L Moreira, S Reilly, KH Ang, D Wang, ...
International Journal of Molecular Sciences 22 (20), 11293, 2021
The mutational concordance of fixed formalin paraffin embedded and fresh frozen gastro-oesophageal tumours using whole exome sequencing
IY Chong, N Starling, A Rust, J Alexander, L Aronson, ...
Journal of Clinical Medicine 10 (2), 215, 2021
SMG8/SMG9 heterodimer loss modulates SMG1 kinase to drive ATR inhibitor resistance
MJ Llorca-Cardenosa, LI Aronson, DB Krastev, J Nieminuszczy, ...
Cancer Research 82 (21), 3962-3973, 2022
Assessment of the molecular heterogeneity of E-cadherin expression in invasive lobular breast cancer
J Alexander, O Mariani, C Meaudre, L Fuhrmann, H Xiao, K Naidoo, ...
Cancers 14 (2), 295, 2022
Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
I Bajrami, C Walker, DB Krastev, D Weekes, F Song, AJ Wicks, ...
Communications biology 4 (1), 1270, 2021
Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor resistant advanced breast cancer
E Harvey-Jones, M Raghunandan, L Robbez-Masson, L Magraner-Pardo, ...
Annals of Oncology, 2024
MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
A Zelceski, P Francica, L Lingg, M Mutlu, C Stok, M Liptay, J Alexander, ...
Cell reports 42 (5), 2023
Longitudinal analysis of PARP inhibitor and platinum resistance in BRCA1/2m breast cancer using liquid biopsy
E Harvey-Jones, M Raghunandan, L Robbez-Masson, A Thanussuyah, ...
Cancer Research 83 (7_Supplement), 6094-6094, 2023
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Články 1–20