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Amanda Lukens
Amanda Lukens
Unknown affiliation
Verified email at broadinstitute.org
Title
Cited by
Cited by
Year
A genome-wide map of diversity in Plasmodium falciparum
SK Volkman, PC Sabeti, D DeCaprio, DE Neafsey, SF Schaffner, ...
Nature genetics 39 (1), 113-119, 2007
3752007
Clinical sequencing uncovers origins and evolution of Lassa virus
KG Andersen, BJ Shapiro, CB Matranga, R Sealfon, AE Lin, LM Moses, ...
Cell 162 (4), 738-750, 2015
2452015
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
N Kato, E Comer, T Sakata-Kato, A Sharma, M Sharma, M Maetani, ...
Nature 538 (7625), 344-349, 2016
2152016
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
AN Cowell, ES Istvan, AK Lukens, MG Gomez-Lorenzo, M Vanaerschot, ...
Science 359 (6372), 191-199, 2018
1672018
Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparumpopulation divergence
DE Neafsey, SF Schaffner, SK Volkman, D Park, P Montgomery, ...
Genome biology 9 (12), 1-16, 2008
1312008
In Vivo Transcriptome of Plasmodium falciparum Reveals Overexpression of Transcripts That Encode Surface Proteins
JP Daily, KG Le Roch, O Sarr, D Ndiaye, A Lukens, Y Zhou, O Ndir, ...
The Journal of infectious diseases 191 (7), 1196-1203, 2005
1262005
Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite
DJ Park, AK Lukens, DE Neafsey, SF Schaffner, HH Chang, C Valim, ...
Proceedings of the National Academy of Sciences 109 (32), 13052-13057, 2012
1242012
Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum
D Van Tyne, DJ Park, SF Schaffner, DE Neafsey, E Angelino, JF Cortese, ...
PLoS genetics 7 (4), e1001383, 2011
1062011
A broad analysis of resistance development in the malaria parasite
VC Corey, AK Lukens, ES Istvan, MCS Lee, V Franco, P Magistrado, ...
Nature communications 7 (1), 11901, 2016
1042016
Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal
R Daniels, HH Chang, PD SÚne, DC Park, DE Neafsey, SF Schaffner, ...
PloS one 8 (4), e60780, 2013
982013
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials
Y Antonova-Koch, S Meister, M Abraham, MR Luth, S Ottilie, AK Lukens, ...
Science 362 (6419), eaat9446, 2018
802018
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs
JD Herman, LR Pepper, JF Cortese, G Estiu, K Galinsky, V Zuzarte-Luis, ...
Science translational medicine 7 (288), 288ra77-288ra77, 2015
682015
Diversity-oriented synthesis yields a novel lead for the treatment of malaria
RW Heidebrecht Jr, C Mulrooney, CP Austin, RH Barker Jr, JA Beaudoin, ...
ACS medicinal chemistry letters 3 (2), 112-117, 2012
672012
Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance
AK Lukens, LS Ross, R Heidebrecht, F Javier Gamo, ...
Proceedings of the National Academy of Sciences 111 (2), 799-804, 2014
632014
Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate
S Hameed P, S Solapure, V Patil, PP Henrich, PA Magistrado, S Bharath, ...
Nature Communications 6 (1), 6715, 2015
572015
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections
M McPhillie, Y Zhou, K El Bissati, J Dubey, H Lorenzi, M Capper, ...
Scientific reports 6 (1), 29179, 2016
402016
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections
M McPhillie, Y Zhou, K El Bissati, J Dubey, H Lorenzi, M Capper, ...
Scientific reports 6 (1), 29179, 2016
402016
Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents
E Comer, JA Beaudoin, N Kato, ME Fitzgerald, RW Heidebrecht, ...
Journal of medicinal chemistry 57 (20), 8496-8502, 2014
392014
SNP Genotyping Identifies New Signatures of Selection in a Deep Sample of West African Plasmodium falciparum Malaria Parasites
A Amambua-Ngwa, DJ Park, SK Volkman, KG Barnes, AK Bei, AK Lukens, ...
Molecular biology and evolution 29 (11), 3249-3253, 2012
382012
Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal
D Ndiaye, B Dieye, YD Ndiaye, D Van Tyne, R Daniels, AK Bei, A Mbaye, ...
International Journal for Parasitology: Drugs and Drug Resistance 3, 135-142, 2013
352013
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