| Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome CM Oslowski, T Hara, B O'Sullivan-Murphy, K Kanekura, S Lu, M Hara, ... Cell metabolism 16 (2), 265-273, 2012 | 678 | 2012 |
| Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8) K Kanekura, I Nishimoto, S Aiso, M Matsuoka Journal of biological chemistry 281 (40), 30223-30233, 2006 | 250 | 2006 |
| ER stress and unfolded protein response in amyotrophic lateral sclerosis K Kanekura, H Suzuki, S Aiso, M Matsuoka Molecular neurobiology 39, 81-89, 2009 | 173 | 2009 |
| ALS‐linked P56S‐VAPB, an aggregated loss‐of‐function mutant of VAPB, predisposes motor neurons to ER stress‐related death by inducing aggregation of co‐expressed wild‐type VAPB H Suzuki, K Kanekura, TP Levine, K Kohno, VM Olkkonen, S Aiso, ... Journal of neurochemistry 108 (4), 973-985, 2009 | 172 | 2009 |
| Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation K Kanekura, T Yagi, AJ Cammack, J Mahadevan, M Kuroda, MB Harms, ... Human molecular genetics 25 (9), 1803-1813, 2016 | 170 | 2016 |
| Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis J Nakahara, K Kanekura, M Nawa, S Aiso, N Suzuki The Journal of clinical investigation 119 (1), 2008 | 157 | 2008 |
| A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome S Lu, K Kanekura, T Hara, J Mahadevan, LD Spears, CM Oslowski, ... Proceedings of the National Academy of Sciences 111 (49), E5292-E5301, 2014 | 156 | 2014 |
| Calcium efflux from the endoplasmic reticulum leads to β-cell death T Hara, J Mahadevan, K Kanekura, M Hara, S Lu, F Urano Endocrinology 155 (3), 758-768, 2014 | 154 | 2014 |
| Involvement of c‐Jun N‐terminal kinase in amyloid precursor protein‐mediated neuronal cell death Y Hashimoto, O Tsuji, T Niikura, Y Yamagishi, M Ishizaka, M Kawasumi, ... Journal of neurochemistry 84 (4), 864-877, 2003 | 128 | 2003 |
| Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants K Kanekura, Y Hashimoto, T Niikura, S Aiso, M Matsuoka, I Nishimoto Journal of Biological Chemistry 279 (18), 19247-19256, 2004 | 121 | 2004 |
| A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant … K Kanekura, Y Hashimoto, Y Kita, J Sasabe, S Aiso, I Nishimoto, ... Journal of biological chemistry 280 (6), 4532-4543, 2005 | 116 | 2005 |
| Characterization of the toxic mechanism triggered by Alzheimer's amyloid‐β peptides via p75 neurotrophin receptor in neuronal hybrid cells E Tsukamoto, Y Hashimoto, K Kanekura, T Niikura, S Aiso, I Nishimoto Journal of neuroscience research 73 (5), 627-636, 2003 | 110 | 2003 |
| Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells AN Vomund, BH Zinselmeyer, J Hughes, B Calderon, C Valderrama, ... Proceedings of the National Academy of Sciences 112 (40), E5496-E5502, 2015 | 107 | 2015 |
| Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by … K Terashita, Y Hashimoto, T Niikura, H Tajima, Y Yamagishi, M Ishizaka, ... Journal of Neurochemistry 85 (6), 1521-1538, 2003 | 100 | 2003 |
| Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal A Kawasaki, K Torii, Y Yamashita, K Nishizawa, K Kanekura, M Katada, ... Cellular signalling 19 (12), 2498-2506, 2007 | 86 | 2007 |
| Molecular mechanisms for neuronal cell death by Alzheimer’s amyloid precursor protein-relevant insults M Kawasumi, Y Hashimoto, T Chiba, K Kanekura, Y Yamagishi, ... Neurosignals 11 (5), 236-250, 2002 | 81 | 2002 |
| Transforming growth factor β2 is a neuronal death-inducing ligand for amyloid-β precursor protein Y Hashimoto, T Chiba, M Yamada, M Nawa, K Kanekura, H Suzuki, ... Molecular and cellular biology, 2005 | 58 | 2005 |
| Therapeutic potential of PLK1 inhibition in triple-negative breast cancer A Ueda, K Oikawa, K Fujita, A Ishikawa, E Sato, T Ishikawa, M Kuroda, ... Laboratory investigation 99 (9), 1275-1286, 2019 | 52 | 2019 |
| Acerola exosome-like nanovesicles to systemically deliver nucleic acid medicine via oral administration T Umezu, M Takanashi, Y Murakami, S Ohno, K Kanekura, K Sudo, ... Molecular Therapy-Methods & Clinical Development 21, 199-208, 2021 | 50 | 2021 |
| A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A … M Nawa, K Kanekura, Y Hashimoto, S Aiso, M Matsuoka Cellular signalling 20 (3), 493-505, 2008 | 49 | 2008 |
Fumihiko UranoSamuel E. Schechter Professor of Medicine, Washington University School of MedicineVerified email at wustl.edu
