| Awakening guardian angels: drugging the p53 pathway CJ Brown, S Lain, CS Verma, AR Fersht, DP Lane Nature Reviews Cancer 9 (12), 862-873, 2009 | 1093 | 2009 |
| Stapled peptides with improved potency and specificity that activate p53 CJ Brown, ST Quah, J Jong, AM Goh, PC Chiam, KH Khoo, ML Choong, ... ACS chemical biology 8 (3), 506-512, 2013 | 247 | 2013 |
| Functionalised staple linkages for modulating the cellular activity of stapled peptides YH Lau, P de Andrade, ST Quah, M Rossmann, L Laraia, N Sköld, ... Chemical Science 5 (5), 1804-1809, 2014 | 205 | 2014 |
| Reactivation of p53: from peptides to small molecules CJ Brown, CF Cheok, CS Verma, DP Lane Trends in pharmacological sciences 32 (1), 53-62, 2011 | 153 | 2011 |
| Differential binding of p53 and nutlin to MDM2 and MDMX: Computational studies TL Joseph, A Madhumalar, CJ Brown, DP Lane, CS Verma Cell Cycle 9 (6), 1167-1181, 2010 | 113 | 2010 |
| Molecular rotors as conditionally fluorescent labels for rapid detection of biomolecular interactions WL Goh, MY Lee, TL Joseph, ST Quah, CJ Brown, C Verma, S Brenner, ... Journal of the American Chemical Society 136 (17), 6159-6162, 2014 | 111 | 2014 |
| Mdm2 and p53 are highly conserved from placozoans to man DP Lane, CF Cheok, C Brown, A Madhumalar, FJ Ghadessy, C Verma Cell Cycle 9 (3), 540-547, 2010 | 99 | 2010 |
| Crystallographic and mass spectrometric characterisation of eIF4E with N 7-alkylated cap derivatives CJ Brown, I McNae, PM Fischer, MD Walkinshaw Journal of molecular biology 372 (1), 7-15, 2007 | 85 | 2007 |
| bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA) S Lim, R Khoo, KM Peh, J Teo, SC Chang, S Ng, GL Beilhartz, RA Melnyk, ... Proceedings of the National Academy of Sciences 117 (11), 5791-5800, 2020 | 79 | 2020 |
| Rational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces D Lama, ST Quah, CS Verma, R Lakshminarayanan, RW Beuerman, ... Scientific reports 3 (1), 3451, 2013 | 74 | 2013 |
| Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges TK Sawyer, AW Partridge, HYK Kaan, YC Juang, S Lim, C Johannes, ... Bioorganic & medicinal chemistry 26 (10), 2807-2815, 2018 | 61 | 2018 |
| Mechanism-specific signatures for small-molecule p53 activators IMM van Leeuwen, M Higgins, J Campbell, CJ Brown, AR McCarthy, ... Cell cycle 10 (10), 1590-1598, 2011 | 60 | 2011 |
| New insights into p53 based therapy. DP Lane, CJ Brown, C Verma, CF Cheok Discovery medicine 12 (63), 107-117, 2011 | 55 | 2011 |
| Assessing the efficacy of Mdm2/Mdm4-inhibiting stapled peptides using cellular thermal shift assays BX Tan, CJ Brown, FJ Ferrer, TY Yuen, ST Quah, BH Chan, AE Jansson, ... Scientific reports 5 (1), 1-9, 2015 | 52 | 2015 |
| Assessing the efficacy of Mdm2/Mdm4-inhibiting stapled peptides using cellular thermal shift assays BX Tan, CJ Brown, FJ Ferrer, TY Yuen, ST Quah, BH Chan, AE Jansson, ... Scientific reports 5 (1), 12116, 2015 | 52 | 2015 |
| Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties AW Partridge, HYK Kaan, YC Juang, A Sadruddin, S Lim, CJ Brown, S Ng, ... Molecules 24 (12), 2292, 2019 | 50 | 2019 |
| Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design YS Tan, J Reeks, CJ Brown, D Thean, FJ Ferrer Gago, TY Yuen, ETL Goh, ... The journal of physical chemistry letters 7 (17), 3452-3457, 2016 | 45 | 2016 |
| The Fluorescent Two-Hybrid Assay to Screen for Protein–Protein Interaction Inhibitors in Live Cells: Targeting the Interaction of p53 with Mdm2 and Mdm4 L Yurlova, M Derks, A Buchfellner, I Hickson, M Janssen, D Morrison, ... Journal of biomolecular screening 19 (4), 516-525, 2014 | 45 | 2014 |
| Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2 SMQ Chee, J Wongsantichon, QS Tng, R Robinson, TL Joseph, C Verma, ... PLoS One 9 (8), e104914, 2014 | 44 | 2014 |
| Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site CJ Brown, CS Verma, MD Walkinshaw, DP Lane Cell Cycle 8 (12), 1905-1911, 2009 | 41 | 2009 |
