Sudarshan Rajagopal
Sudarshan Rajagopal
Division of Cardiology, Duke University Medical Center
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Teaching old receptors new tricks: biasing seven-transmembrane receptors
S Rajagopal, K Rajagopal, RJ Lefkowitz
Nature reviews Drug discovery 9 (5), 373-386, 2010
β-arrestin-but not G protein-mediated signaling by the “decoy” receptor CXCR7
S Rajagopal, J Kim, S Ahn, S Craig, CM Lam, NP Gerard, C Gerard, ...
Proceedings of the National Academy of Sciences 107 (2), 628-632, 2010
Distinct phosphorylation sites on the β2-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin
KN Nobles, K Xiao, S Ahn, AK Shukla, CM Lam, S Rajagopal, ...
Science signaling 4 (185), ra51-ra51, 2011
Therapeutic potential of β-arrestin-and G protein-biased agonists
EJ Whalen, S Rajagopal, RJ Lefkowitz
Trends in molecular medicine 17 (3), 126-139, 2011
The LOV domain family: photoresponsive signaling modules coupled to diverse output domains
S Crosson, S Rajagopal, K Moffat
Biochemistry 42 (1), 2-10, 2003
Biased signalling: from simple switches to allosteric microprocessors
JS Smith, RJ Lefkowitz, S Rajagopal
Nature reviews Drug discovery 17 (4), 243-260, 2018
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
MR Hara, JJ Kovacs, EJ Whalen, S Rajagopal, RT Strachan, W Grant, ...
Nature 477 (7364), 349-353, 2011
Quantifying ligand bias at seven-transmembrane receptors
S Rajagopal, S Ahn, DH Rominger, W Gowen-MacDonald, CM Lam, ...
Molecular pharmacology 80 (3), 367-377, 2011
Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds
H Ihee, S Rajagopal, V ©rajer, R Pahl, S Anderson, M Schmidt, F Schotte, ...
Proceedings of the National Academy of Sciences 102 (20), 7145-7150, 2005
The β-arrestins: multifunctional regulators of G protein-coupled receptors
JS Smith, S Rajagopal
Journal of Biological Chemistry 291 (17), 8969-8977, 2016
Multiple ligand-specific conformations of the β 2-adrenergic receptor
AW Kahsai, K Xiao, S Rajagopal, S Ahn, AK Shukla, J Sun, TG Oas, ...
Nature chemical biology 7 (10), 692-700, 2011
GPCR desensitization: Acute and prolonged phases
S Rajagopal, SK Shenoy
Cellular signalling 41, 9-16, 2018
Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)
K Xiao, J Sun, J Kim, S Rajagopal, B Zhai, J Villén, W Haas, JJ Kovacs, ...
Proceedings of the National Academy of Sciences 107 (34), 15299-15304, 2010
Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9
LM Luttrell, J Wang, B Plouffe, JS Smith, L Yamani, S Kaur, ...
Science Signaling 11 (549), eaat7650, 2018
Application of singular value decomposition to the analysis of time-resolved macromolecular X-ray data
M Schmidt, S Rajagopal, Z Ren, K Moffat
Biophysical journal 84 (3), 2112-2129, 2003
Biased agonism as a mechanism for differential signaling by chemokine receptors
S Rajagopal, DL Bassoni, JJ Campbell, NP Gerard, C Gerard, ...
Journal of Biological Chemistry 288 (49), 35039-35048, 2013
Purification and Initial Characterization of a Putative Blue Light‐regulated Phosphodiesterase from Escherichia coli
S Rajagopal, JM Key, EB Purcell, DJ Boerema, K Moffat
Photochemistry and photobiology 80 (3), 542-547, 2004
Protein kinetics: structures of intermediates and reaction mechanism from time-resolved x-ray data
M Schmidt, R Pahl, V Srajer, S Anderson, Z Ren, H Ihee, S Rajagopal, ...
Proceedings of the National Academy of Sciences 101 (14), 4799-4804, 2004
How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways
K Rajarathnam, M Schnoor, RM Richardson, S Rajagopal
Cellular signalling 54, 69-80, 2019
Comprehensive assessment of right ventricular function in patients with pulmonary hypertension with global longitudinal peak systolic strain derived from multiple right …
S Rajagopal, DE Forsha, N Risum, CP Hornik, AD Poms, TA Fortin, ...
Journal of the American Society of Echocardiography 27 (6), 657-665. e3, 2014
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