| Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes P Rezacova, J Pokorná, J Brynda, M Kozisek, P Cigler, M Lepsik, ... Journal of medicinal chemistry 52 (22), 7132-7141, 2009 | 158 | 2009 |
| Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance M Kožíšek, P Cígler, M Lepšík, J Fanfrlík, P Řezáčová, J Brynda, ... Journal of medicinal chemistry 51 (15), 4839-4843, 2008 | 112 | 2008 |
| Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants M Kožíšek, J Bray, P Řezáčová, K Šašková, J Brynda, J Pokorná, ... Journal of molecular biology 374 (4), 1005-1016, 2007 | 105 | 2007 |
| Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold J Schimer, P Cígler, J Vesely, K Grantz Šašková, M Lepsik, J Brynda, ... Journal of Medicinal Chemistry 55 (22), 10130-10135, 2012 | 67 | 2012 |
| Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir KG Šašková, M Kožíšek, P Rˇezácová, J Brynda, T Yashina, ... Journal of virology 83 (17), 8810-8818, 2009 | 67 | 2009 |
| Thermodynamic and structural analysis of HIV protease resistance to darunavir–analysis of heavily mutated patient‐derived HIV‐1 proteases M Kožíšek, M Lepšík, K Grantz Šašková, J Brynda, J Konvalinka, ... The FEBS journal 281 (7), 1834-1847, 2014 | 63 | 2014 |
| Human DNA-damage-inducible 2 protein is structurally and functionally distinct from its yeast ortholog M Sivá, M Svoboda, V Veverka, JF Trempe, K Hofmann, M Kožíšek, ... Scientific reports 6 (1), 30443, 2016 | 59 | 2016 |
| Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region M Kožíšek, KG Šašková, P Řezáčová, J Brynda, ... Journal of virology 82 (12), 5869-5878, 2008 | 57 | 2008 |
| Mutations in HIV-1 gag and pol Compensate for the Loss of Viral Fitness Caused by a Highly Mutated Protease M Kožíšek, S Henke, KG Šašková, GB Jacobs, A Schuch, B Buchholz, ... Antimicrobial agents and chemotherapy 56 (8), 4320-4330, 2012 | 53 | 2012 |
| Specific inhibitors of HIV capsid assembly binding to the C-terminal domain of the capsid protein: evaluation of 2-arylquinazolines as potential antiviral compounds A Machara, V Lux, M Kožíšek, K Grantz Šašková, O Štěpánek, ... Journal of medicinal chemistry 59 (2), 545-558, 2016 | 43 | 2016 |
| Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family JF Trempe, KG Šašková, M Sivá, CDH Ratcliffe, V Veverka, A Hoegl, ... Scientific reports 6 (1), 33671, 2016 | 41 | 2016 |
| The yeast proteases Ddi1 and Wss1 are both involved in the DNA replication stress response M Svoboda, J Konvalinka, JF Trempe, KG Saskova DNA repair 80, 45-51, 2019 | 39 | 2019 |
| Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome J Ramirez, B Lectez, N Osinalde, M Sivá, N Elu, K Aloria, M Procházková, ... Human Molecular Genetics 27 (11), 1955-1971, 2018 | 35 | 2018 |
| Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir KG Šašková, M Kožíšek, M Lepšík, J Brynda, P Řezáčová, J Václavíková, ... Protein Science 17 (9), 1555-1564, 2008 | 35 | 2008 |
| Nelfinavir inhibits the TCF11/Nrf1-mediated proteasome recovery pathway in multiple myeloma D Fassmannová, F Sedlák, J Sedláček, I Špička, K Grantz Šašková Cancers 12 (5), 1065, 2020 | 30 | 2020 |
| Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopy P Srb, M Svoboda, L Benda, M Lepšík, J Tarábek, V Šícha, B Grüner, ... Physical Chemistry Chemical Physics 21 (10), 5661-5673, 2019 | 22 | 2019 |
| Lipid Nanoparticles for Broad‐Spectrum Nucleic Acid Delivery Z Hejdankova, V Vanek, F Sedlak, J Prochazka, A Diederichs, S Kereïche, ... Advanced Functional Materials 31 (47), 2101391, 2021 | 13 | 2021 |
| Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies V Bartoňová, V Král, I Sieglová, J Brynda, M Fábry, M Hořejší, M Kožíšek, ... Antiviral research 78 (3), 275-277, 2008 | 13 | 2008 |
| GS-8374, a prototype phosphonate-containing inhibitor of HIV-1 protease, effectively inhibits protease mutants with amino acid insertions K Grantz Šašková, M Kožíšek, K Stray, D de Jong, P Řezáčová, J Brynda, ... Journal of Virology 88 (6), 3586-3590, 2014 | 8 | 2014 |
| Backbone 1H, 13C, and 15N NMR assignment for the inactive form of the retroviral protease of the murine intracisternal A-type particle, inMIA-14 PR V Motáčková, M Kubíčková, M Kožíšek, KG Šašková, M Švec, L Žídek, ... Biomolecular NMR assignments 3, 261-264, 2009 | 6 | 2009 |
