Rama Khokha

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Josef PenningerLife Sciences Institute, University of British Columbia / IMBA Institut für MolekulareVerified email at imba.oeaw.ac.at
Jimmie E. FataAssociate Professor, Department of Biology, College of Staten Island, City University of New YorkVerified email at csi.cuny.edu
Purna JoshiUniversity of Texas at DallasVerified email at utdallas.edu
Sam MolyneuxUniversity of TorontoVerified email at uhnres.utoronto.ca
Ming TsaoProfessor of Laboratory Medicine and Pathobiology, University of Toronto, Senior Scientist and Consultant Pathologist, Princess Verified email at uhn.ca
Alexander BeristainAssistant Professor, The University of British ColumbiaVerified email at mail.ubc.ca
Peeyush Laladepartment of anatomy and cell biology, university of western ontarioVerified email at uwo.ca
Peter H Backxdepartment of biology York universityVerified email at yorku.ca
Trevor McKeeAdjunct Lecturer, Department of Laboratory Medicine and Pathobiology, University of TorontoVerified email at utoronto.ca
Andrew Tri Van HoScientist, Université Paris CitéVerified email at u-paris.fr
Gordon DuncanTreadwell Therapeutics Inc. , Toronto, CanadaVerified email at treadwelltx.com
S. Jeffrey DixonDistinguished University Professor Emeritus, Western University, London, CanadaVerified email at schulich.uwo.ca
Stefano MeniniDepartment of Clinical and Molecular Medicine, Sapienza University of RomeVerified email at uniroma1.it
ormandy cjVerified email at garvan.org.au
Daniel SchramekSenior Investigator & Assoc. Prof. Mount Sinai Hospital/University of TorontoVerified email at lunenfeld.ca
James W. DennisProfessor of Molecular Genetics, University of TorontoVerified email at lunenfeld.ca
Marta Letizia HribalUniversità di Catanzaro Magna GraeciaVerified email at unicz.it
Paul W.M. Fedak, M.D. Ph.D.University of Calgary and Northwestern UniversityVerified email at ucalgary.ca

Rama Khokha

Professor, University of Toronto, Ontario cancer institute

Verified email at uhnres.utoronto.ca

metalloproteinases stem cells inflammation cancer metastasis


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Regulation of cancer cell migration and bone metastasis by RANKL DH Jones, T Nakashima, OH Sanchez, I Kozieradzki, SV Komarova, ... Nature 440 (7084), 692-696, 2006	937	2006
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development JE Fata, YY Kong, J Li, T Sasaki, J Irie-Sasaki, RA Moorehead, R Elliott, ... Cell 103 (1), 41-50, 2000	923	2000
Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression IS Harris, AE Treloar, S Inoue, M Sasaki, C Gorrini, KC Lee, KY Yung, ... Cancer cell 27 (2), 211-222, 2015	796	2015
Progesterone induces adult mammary stem cell expansion PA Joshi, HW Jackson, AG Beristain, MA Di Grappa, PA Mote, CL Clarke, ... Nature 465 (7299), 803-807, 2010	731	2010
Suppression of tumor growth and metastasis in Mgat5-deficient mice M Granovsky, J Fata, J Pawling, WJ Muller, R Khokha, JW Dennis Nature medicine 6 (3), 306-312, 2000	620	2000
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. KJ Leco, R Khokha, N Pavloff, SP Hawkes, DR Edwards Journal of Biological Chemistry 269 (12), 9352-9360, 1994	616	1994
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer D Schramek, A Leibbrandt, V Sigl, L Kenner, JA Pospisilik, HJ Lee, ... Nature 468 (7320), 98-102, 2010	599	2010
Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells R Khokha, P Waterhouse, S Yagel, PK Lala, CM Overall, G Norton, ... Science 243 (4893), 947-950, 1989	585	1989
Metalloproteinases and their natural inhibitors in inflammation and immunity R Khokha, A Murthy, A Weiss Nature Reviews Immunology 13 (9), 649-665, 2013	564	2013
Tumor necrosis factor-α mediates cardiac remodeling and ventricular dysfunction after pressure overload state M Sun, M Chen, F Dawood, U Zurawska, JY Li, T Parker, Z Kassiri, ... Circulation 115 (11), 1398-1407, 2007	451	2007
The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer T Li, L Sun, N Miller, T Nicklee, J Woo, L Hulse-Smith, MS Tsao, R Khokha, ... Cancer Epidemiology Biomarkers & Prevention 14 (2), 343-349, 2005	394	2005
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis A Hakem, O Sanchez-Sweatman, A You-Ten, G Duncan, A Wakeham, ... Genes & development 19 (17), 1974-1979, 2005	378	2005
Molecular mechanisms of tumor invasion and metastasis: an integrated view RA Cairns, R Khokha, RP Hill Current molecular medicine 3 (7), 659-671, 2003	361	2003
Steps in tumor metastasis: new concepts from intravital videomicroscopy AF Chambers, IC MacDonald, EE Schmidt, S Koop, VL Morris, R Khokha, ... Cancer and Metastasis Reviews 14, 279-301, 1995	357	1995
Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3) KJ Leco, P Waterhouse, OH Sanchez, KLM Gowing, AR Poole, ... The Journal of clinical investigation 108 (6), 817-829, 2001	345	2001
TIMPs: versatile extracellular regulators in cancer HW Jackson, V Defamie, P Waterhouse, R Khokha Nature Reviews Cancer 17 (1), 38-53, 2017	342	2017
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS DR McIlwain, PA Lang, T Maretzky, K Hamada, K Ohishi, SK Maney, ... Science 335 (6065), 229-232, 2012	342	2012
Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution S Schenk, E Hintermann, M Bilban, N Koshikawa, C Hojilla, R Khokha, ... The Journal of cell biology 161 (1), 197-209, 2003	340	2003
Abnormal TNF activity in Timp3^−/− mice leads to chronic hepatic inflammation and failure of liver regeneration FF Mohammed, DS Smookler, SEM Taylor, B Fingleton, Z Kassiri, ... Nature genetics 36 (9), 969-977, 2004	334	2004
Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development CV Hojilla, FF Mohammed, R Khokha British journal of cancer 89 (10), 1817-1821, 2003	314	2003

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