Juan Mendez (ORCID:0000-0002-3235-2559)

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Bruce StillmanCold Spring Harbor LaboratoryVerified email at cshl.edu
Oscar Fernandez-CapetilloGenomic Instability Group, Spanish National Cancer Research Centre (CNIO)Verified email at cnio.es
Tomas AparicioAssociate Research ScientistVerified email at columbia.edu
Marcos MalumbresSpanish National Cancer Research Centre (CNIO)Verified email at cnio.es
Javier MuñozBiocruces BizkaiaVerified email at osakidetza.eus
Estrella Sandra ChocronInstructor Barshop InstituteVerified email at uthscsa.edu
Marta CanameroPathology, Translational Medicine, Oncology, ROCHEVerified email at roche.com
Blasco MA (0000-0002-4211-233X)Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIOVerified email at cnio.es
Sergio MorenoCSICVerified email at usal.es
IRENE GARCÍA-HIGUERAInstituto de Biología Funcional y Genómica (IBFG) SalamancaVerified email at usal.es
Luis Rodriguez-BorladoVP Regenerative Therapies. Capricor TherapeuticsVerified email at capricor.com
Isabel RuppenCentro Nacional de Investigaciones OncológicasVerified email at cnio.es
Ciaran MorrisonProfessor, Centre for Chromosome Biology, National University of Ireland GalwayVerified email at nuigalway.ie
Eric PietrasUniversity of Colorado Anschutz Medical CampusVerified email at cuanschutz.edu
Mary MohrinSenior Scientist, GenentechVerified email at gene.com
Fernando UgarteMerckVerified email at merck.com
Sietske BakkerPostdoctoral Fellow, UCSFVerified email at stemcell.ucsf.edu
Eusebio ManchadoResearch Scholar, Memorial Sloan Kettering Cancer Center (MSKCC)Verified email at cnio.es
Eduardo SalidoHospital Universitario Canarias, Universidad La LagunaVerified email at ull.es
i j holtBiodonostia Research InstituteVerified email at biodonostia.org

Juan Mendez (ORCID:0000-0002-3235-2559)

Lab Head, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

Verified email at cnio.es - Homepage

DNA replication genomic stability


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Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis J Méndez, B Stillman Molecular and cellular biology 20 (22), 8602-8612, 2000	1026	2000
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells J Flach, ST Bakker, M Mohrin, PC Conroy, EM Pietras, D Reynaud, ... Nature 512 (7513), 198-202, 2014	502	2014
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication A Ibarra, E Schwob, J Méndez Proceedings of the National Academy of Sciences 105 (26), 8956-8961, 2008	469	2008
Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication J Méndez, XH Zou-Yang, SY Kim, M Hidaka, WP Tansey, B Stillman Molecular cell 9 (3), 481-491, 2002	379	2002
Genomic stability and tumour suppression by the APC/C cofactor Cdh1 I García-Higuera, E Manchado, P Dubus, M Cañamero, J Méndez, ... Nature cell biology 10 (7), 802-811, 2008	363	2008
Deregulation of cyclin E in human cells interferes with prereplication complex assembly S Ekholm-Reed, J Méndez, D Tedesco, A Zetterberg, B Stillman, SI Reed The Journal of cell biology 165 (6), 789-800, 2004	347	2004
PrimPol, an archaic primase/polymerase operating in human cells S García-Gómez, A Reyes, MI Martínez-Jiménez, ES Chocrón, S Mourón, ... Molecular cell 52 (4), 541-553, 2013	342	2013
Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins J Méndez, B Stillman Bioessays 25 (12), 1158-1167, 2003	267	2003
Repriming of DNA synthesis at stalled replication forks by human PrimPol S Mourón, S Rodriguez-Acebes, MI Martínez-Jiménez, S García-Gómez, ... Nature structural & molecular biology 20 (12), 1383-1389, 2013	249	2013
CDC6: from DNA replication to cell cycle checkpoints and oncogenesis LR Borlado, J Méndez carcinogenesis 29 (2), 237-243, 2008	243	2008
Cohesin organizes chromatin loops at DNA replication factories E Guillou, A Ibarra, V Coulon, J Casado-Vela, D Rico, I Casal, E Schwob, ... Genes & development 24 (24), 2812-2822, 2010	222	2010
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells AK Ahuja, K Jodkowska, F Teloni, AH Bizard, R Zellweger, R Herrador, ... Nature communications 7 (1), 1-11, 2016	156	2016
Initiation of phi 29 DNA replication occurs at the second 3'nucleotide of the linear template: a sliding-back mechanism for protein-primed DNA replication. J Mendez, L Blanco, JA Esteban, A Bernad, M Salas Proceedings of the National Academy of Sciences 89 (20), 9579-9583, 1992	137	1992
USP7 is a SUMO deubiquitinase essential for DNA replication E Lecona, S Rodriguez-Acebes, J Specks, AJ Lopez-Contreras, I Ruppen, ... Nature structural & molecular biology 23 (4), 270-277, 2016	122	2016
The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication T Aparicio, E Guillou, J Coloma, G Montoya, J Mendez Nucleic acids research 37 (7), 2087-2095, 2009	121	2009
A proteomic characterization of factors enriched at nascent DNA molecules AJ Lopez-Contreras, I Ruppen, M Nieto-Soler, M Murga, ... Cell reports 3 (4), 1105-1116, 2013	111	2013
Dynamics of pre-replication complex proteins during the cell division cycle SG Prasanth, J Méndez, KV Prasanth, B Stillman Philosophical Transactions of the Royal Society of London. Series B …, 2004	105	2004
Cdc45-MCM-GINS, a new power player for DNA replication T Aparicio, A Ibarra, J Méndez Cell division 1 (1), 1-5, 2006	99	2006
PRIMPOL-mediated adaptive response suppresses replication fork reversal in BRCA-deficient cells A Quinet, S Tirman, J Jackson, S Šviković, D Lemaçon, ... Molecular cell 77 (3), 461-474. e9, 2020	93	2020
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality S Alvarez, M Díaz, J Flach, S Rodriguez-Acebes, AJ López-Contreras, ... Nature communications 6 (1), 1-11, 2015	92	2015

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