Francesc Xavier Ruiz
Francesc Xavier Ruiz
Assistant Professor, Center for Advanced Biotechnology & Medicine, Rutgers University, New Jersey
E-mailová adresa ověřena na:
Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53
D Martinez-Zapien, FX Ruiz, J Poirson, A Mitschler, J Ramirez, A Forster, ...
Nature 529 (7587), 541-545, 2016
Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10
O Gallego, FX Ruiz, A Ardèvol, M Domínguez, R Alvarez, AR De Lera, ...
Proceedings of the National Academy of Sciences 104 (52), 20764-20769, 2007
Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids
O Gallego, OV Belyaeva, S Porté, FX Ruiz, AV Stetsenko, EV Shabrova, ...
Biochemical Journal 399 (1), 101-109, 2006
Modulation of aldose reductase inhibition by halogen bond tuning
J Fanfrlík, M Kolář, M Kamlar, D Hurný, FX Ruiz, A Cousido-Siah, ...
ACS chemical biology 8 (11), 2484-2492, 2013
Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels
FX Ruiz, O Gallego, A Ardèvol, A Moro, M Domínguez, S Alvarez, ...
Chemico-biological interactions 178 (1-3), 171-177, 2009
Biological role of aldo–keto reductases in retinoic acid biosynthesis and signaling
FX Ruiz, S Porté, X Parés, J Farrés
Frontiers in pharmacology 3, 58, 2012
Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of …
MC Van Zandt, DL Whitehouse, A Golebiowski, MK Ji, M Zhang, ...
Journal of Medicinal Chemistry 56 (6), 2568-2580, 2013
The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition ACS Chem
J Fanfrlík, FX Ruiz, A Kadlčíková, J Řezáč, A Cousido-Siah, A Mitschler, ...
Biol 10, 1637-1642, 2015
Eukaryotic translation-initiation factor eIF2β binds to protein kinase CK2: effects on CK2α activity
F Llorens, N Roher, FA Miró, S Sarno, FX Ruiz, F Meggio, M Plana, ...
Biochemical Journal 375 (3), 623-631, 2003
Retinaldehyde is a substrate for human aldo–keto reductases of the 1C subfamily
FX Ruiz, S Porté, O Gallego, A Moro, A Ardèvol, D Río-Espínola, C Rovira, ...
Biochemical Journal 440 (3), 335-347, 2011
Aldo–keto reductases in retinoid metabolism: search for substrate specificity and inhibitor selectivity
S Porté, FX Ruiz, J Giménez, I Molist, S Alvarez, M Domínguez, R Alvarez, ...
Chemico-biological interactions 202 (1-3), 186-194, 2013
Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction
A Golebiowski, D Whitehouse, RP Beckett, M Van Zandt, MK Ji, TR Ryder, ...
Bioorganic & medicinal chemistry letters 23 (17), 4837-4841, 2013
Human and rodent aldo–keto reductases from the AKR1B subfamily and their specificity with retinaldehyde
FX Ruiz, A Moro, O Gallego, A Ardèvol, C Rovira, JM Petrash, X Parés, ...
Chemico-biological interactions 191 (1-3), 199-205, 2011
X-ray crystal structure of the full length human chitotriosidase (CHIT1) reveals features of its chitin binding domain
F Fadel, Y Zhao, A Cousido-Siah, FX Ruiz, A Mitschler, A Podjarny
PloS one 11 (4), e0154190, 2016
2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors
A Golebiowski, RP Beckett, M Van Zandt, MK Ji, D Whitehouse, TR Ryder, ...
Bioorganic & medicinal chemistry letters 23 (7), 2027-2030, 2013
Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and …
A Cousido-Siah, FX Ruiz, A Mitschler, S Porté, ÁR De Lera, MJ Martín, ...
Acta Crystallographica Section D: Biological Crystallography 70 (3), 889-903, 2014
New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM
F Fadel, Y Zhao, R Cachau, A Cousido-Siah, FX Ruiz, K Harlos, ...
Acta Crystallographica Section D: Biological Crystallography 71 (7), 1455-1470, 2015
A missense mutation in ALDH1A3 causes isolated microphthalmia/anophthalmia in nine individuals from an inbred Muslim kindred
A Mory, FX Ruiz, E Dagan, EA Yakovtseva, A Kurolap, X Parés, J Farrés, ...
European Journal of Human Genetics 22 (3), 419-422, 2014
Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10
A Cousido-Siah, FX Ruiz, I Crespo, S Porté, A Mitschler, X Parés, ...
Chemico-biological interactions 234, 290-296, 2015
Crystal packing modifies ligand binding affinity: The case of aldose reductase
A Cousido‐Siah, T Petrova, I Hazemann, A Mitschler, FX Ruiz, E Howard, ...
Proteins: Structure, Function, and Bioinformatics 80 (11), 2552-2561, 2012
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Články 1–20