Emily E. Scott
Emily E. Scott
Professor, Department of Medicinal Chemistry, University of Michigan
E-mailová adresa ověřena na: umich.edu - Domovská stránka
Název
Citace
Citace
Rok
An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution
EE Scott, YA He, MR Wester, MA White, CC Chin, JR Halpert, EF Johnson, ...
Proceedings of the National Academy of Sciences 100 (23), 13196-13201, 2003
4182003
Mapping the pathways for O2 entry into and exit from myoglobin
EE Scott, QH Gibson, JS Olson
Journal of Biological Chemistry 276 (7), 5177-5188, 2001
3902001
Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl) imidazole at 1.9-Å resolution: insight into the range of P450 conformations and the coordination of …
EE Scott, MA White, YA He, EF Johnson, CD Stout, JR Halpert
Journal of Biological Chemistry 279 (26), 27294-27301, 2004
3432004
Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001
NM DeVore, EE Scott
Nature 482 (7383), 116-119, 2012
2772012
Structures of human cytochrome P-450 2E1: insights into the binding of inhibitors and both small molecular weight and fatty acid substrates
PR Porubsky, KM Meneely, EE Scott
Journal of Biological Chemistry 283 (48), 33698-33707, 2008
2312008
Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism
AA Walsh, GD Szklarz, EE Scott
Journal of Biological Chemistry 288 (18), 12932-12943, 2013
2222013
Ligand migration in sperm whale myoglobin
EE Scott, QH Gibson
Biochemistry 36 (39), 11909-11917, 1997
1741997
A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function
EE Scott, M Spatzenegger, JR Halpert
Archives of Biochemistry and Biophysics 395 (1), 57-68, 2001
1472001
Structures of cytochrome P450 3A4
EE Scott, JR Halpert
Trends in biochemical sciences 30 (1), 5-7, 2005
1232005
Structure of the human lung cytochrome P450 2A13
BD Smith, JL Sanders, PR Porubsky, GH Lushington, CD Stout, EE Scott
Journal of Biological Chemistry 282 (23), 17306-17313, 2007
1072007
Waterproofing the heme pocket: role of proximal amino acid side chains in preventing hemin loss from myoglobin
EC Liong, Y Dou, EE Scott, JS Olson, GN Phillips
Journal of Biological Chemistry 276 (12), 9093-9100, 2001
1012001
Human cytochrome P450 2E1 structures with fatty acid analogs reveal a previously unobserved binding mode
PR Porubsky, KP Battaile, EE Scott
Journal of biological chemistry 285 (29), 22282-22290, 2010
972010
Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR
DF Estrada, JS Laurence, EE Scott
Journal of Biological Chemistry 288 (23), 17008-17018, 2013
842013
Structures of human steroidogenic cytochrome P450 17A1 with substrates
EM Petrunak, NM DeVore, PR Porubsky, EE Scott
Journal of Biological Chemistry 289 (47), 32952-32964, 2014
832014
Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes
NM DeVore, EE Scott
Journal of Biological Chemistry 287 (32), 26576-26585, 2012
712012
Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine
NM DeVore, KM Meneely, AG Bart, ES Stephens, KP Battaile, EE Scott
The FEBS journal 279 (9), 1621-1631, 2012
702012
A rational approach to re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5
S Kumar, EE Scott, H Liu, JR Halpert
Journal of Biological Chemistry 278 (19), 17178-17184, 2003
702003
Possible pathway (s) of testosterone egress from the active site of cytochrome P450 2B1: a steered molecular dynamics simulation
W Li, H Liu, EE Scott, F Gräter, JR Halpert, X Luo, J Shen, H Jiang
Drug metabolism and disposition 33 (7), 910-919, 2005
602005
The stabilities of mammalian apomyoglobins vary over a 600-fold range and can be enhanced by comparative mutagenesis
EE Scott, EV Paster, JS Olson
Journal of Biological Chemistry 275 (35), 27129-27136, 2000
582000
Human Cytochrome P450 17A1 Conformational Selection: Modulation by ligand and cytochrome b5
DF Estrada, AL Skinner, JS Laurence, EE Scott
Journal of Biological Chemistry 289 (20), 14310-14320, 2014
572014
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Články 1–20