Emily E. Scott
Emily E. Scott
Professor, Department of Medicinal Chemistry, University of Michigan
E-mailová adresa ověřena na: - Domovská stránka
An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution
EE Scott, YA He, MR Wester, MA White, CC Chin, JR Halpert, EF Johnson, ...
Proceedings of the National Academy of Sciences 100 (23), 13196-13201, 2003
Mapping the pathways for O2 entry into and exit from myoglobin
EE Scott, QH Gibson, JS Olson
Journal of Biological Chemistry 276 (7), 5177-5188, 2001
Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl) imidazole at 1.9-Å resolution: insight into the range of P450 conformations and the coordination of …
EE Scott, MA White, YA He, EF Johnson, CD Stout, JR Halpert
Journal of Biological Chemistry 279 (26), 27294-27301, 2004
Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001
NM DeVore, EE Scott
Nature 482 (7383), 116-119, 2012
Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism
AA Walsh, GD Szklarz, EE Scott
Journal of Biological Chemistry 288 (18), 12932-12943, 2013
Structures of human cytochrome P-450 2E1: insights into the binding of inhibitors and both small molecular weight and fatty acid substrates
PR Porubsky, KM Meneely, EE Scott
Journal of Biological Chemistry 283 (48), 33698-33707, 2008
Ligand migration in sperm whale myoglobin
EE Scott, QH Gibson
Biochemistry 36 (39), 11909-11917, 1997
A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function
EE Scott, M Spatzenegger, JR Halpert
Archives of Biochemistry and Biophysics 395 (1), 57-68, 2001
Structures of cytochrome P450 3A4
EE Scott, JR Halpert
Trends in biochemical sciences 30 (1), 5-7, 2005
Structure of the human lung cytochrome P450 2A13
BD Smith, JL Sanders, PR Porubsky, GH Lushington, CD Stout, EE Scott
Journal of Biological Chemistry 282 (23), 17306-17313, 2007
Human cytochrome P450 2E1 structures with fatty acid analogs reveal a previously unobserved binding mode
PR Porubsky, KP Battaile, EE Scott
Journal of biological chemistry 285 (29), 22282-22290, 2010
Waterproofing the heme pocket: role of proximal amino acid side chains in preventing hemin loss from myoglobin
EC Liong, Y Dou, EE Scott, JS Olson, GN Phillips
Journal of Biological Chemistry 276 (12), 9093-9100, 2001
Structures of human steroidogenic cytochrome P450 17A1 with substrates
EM Petrunak, NM DeVore, PR Porubsky, EE Scott
Journal of Biological Chemistry 289 (47), 32952-32964, 2014
Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR
DF Estrada, JS Laurence, EE Scott
Journal of Biological Chemistry 288 (23), 17008-17018, 2013
Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes
NM DeVore, EE Scott
Journal of Biological Chemistry 287 (32), 26576-26585, 2012
Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine
NM DeVore, KM Meneely, AG Bart, ES Stephens, KP Battaile, EE Scott
The FEBS journal 279 (9), 1621-1631, 2012
A rational approach to re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5
S Kumar, EE Scott, H Liu, JR Halpert
Journal of Biological Chemistry 278 (19), 17178-17184, 2003
Illuminating cytochrome P450 binding: Ru (ii)-caged inhibitors of CYP17A1
A Li, R Yadav, JK White, MK Herroon, BP Callahan, I Podgorski, C Turro, ...
Chemical Communications 53 (26), 3673-3676, 2017
Human Cytochrome P450 17A1 Conformational Selection: Modulation by ligand and cytochrome b5
DF Estrada, AL Skinner, JS Laurence, EE Scott
Journal of Biological Chemistry 289 (20), 14310-14320, 2014
Possible pathway (s) of testosterone egress from the active site of cytochrome P450 2B1: a steered molecular dynamics simulation
W Li, H Liu, EE Scott, F Gräter, JR Halpert, X Luo, J Shen, H Jiang
Drug metabolism and disposition 33 (7), 910-919, 2005
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Články 1–20