Melissa Sykes
Melissa Sykes
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Development of an Alamar Blue™ viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427
ML Sykes, VM Avery
The American journal of tropical medicine and hygiene 81 (4), 665-674, 2009
Screening the Medicines for Malaria Venture Pathogen Box across multiple pathogens reclassifies starting points for open-source drug discovery
S Duffy, ML Sykes, AJ Jones, TB Shelper, M Simpson, R Lang, ...
Antimicrobial agents and chemotherapy 61 (9), e00379-17, 2017
Synergistic effects of a cellulase-producing Micromonospora carbonacea and an antibiotic-producing Streptomyces violascens on the suppression of Phytophthora cinnamomi root rot …
KA El-Tarabily, ML Sykes, ID Kurtböke, GESJ Hardy, AM Barbosa, ...
Canadian Journal of Botany 74 (4), 618-624, 1996
Identification of Compounds with Anti-Proliferative Activity against Trypanosoma brucei brucei Strain 427 by a Whole Cell Viability Based HTS Campaign
ML Sykes, JB Baell, M Kaiser, E Chatelain, SR Moawad, D Ganame, ...
PLoS neglected tropical diseases 6 (11), e1896, 2012
Approaches to protozoan drug discovery: phenotypic screening: miniperspectives series on phenotypic screening for antiinfective targets
ML Sykes, VM Avery
Journal of medicinal chemistry 56 (20), 7727-7740, 2013
Antiparasitic activity of alkaloids from plant species of Papua New Guinea and Australia
LS Fernandez, ML Sykes, KT Andrews, VM Avery
International journal of antimicrobial agents 36 (3), 275-279, 2010
Antitrypanosomal Cyclic Polyketide Peroxides from the Australian Marine Sponge Plakortis sp.
Y Feng, RA Davis, M Sykes, VM Avery, D Camp, RJ Quinn
Journal of natural products 73 (4), 716-719, 2010
Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei
L Ferrins, M Gazdik, R Rahmani, S Varghese, ML Sykes, AJ Jones, ...
Journal of medicinal chemistry 57 (15), 6393-6402, 2014
Antitrypanosomal pyridoacridine alkaloids from the Australian ascidian Polysyncraton echinatum
Y Feng, RA Davis, ML Sykes, VM Avery, AR Carroll, D Camp, RJ Quinn
Tetrahedron Letters 51 (18), 2477-2479, 2010
Pseudoceramines A–D, new antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp.
S Yin, RA Davis, T Shelper, ML Sykes, VM Avery, M Elofsson, C Sundin, ...
Organic & biomolecular chemistry 9 (19), 6755-6760, 2011
Screening a natural product-based library against kinetoplastid parasites
B Zulfiqar, AJ Jones, ML Sykes, TB Shelper, RA Davis, VM Avery
Molecules 22 (10), 1715, 2017
Development and application of a sensitive, phenotypic, high-throughput image-based assay to identify compound activity against Trypanosoma cruzi amastigotes
ML Sykes, VM Avery
International Journal for Parasitology: Drugs and Drug Resistance 5 (3), 215-228, 2015
Convolutamines I and J, antitrypanosomal alkaloids from the bryozoan Amathia tortusa
RA Davis, M Sykes, VM Avery, D Camp, RJ Quinn
Bioorganic & medicinal chemistry 19 (22), 6615-6619, 2011
Ianthelliformisamines A–C, Antibacterial Bromotyrosine-Derived Metabolites from the Marine Sponge Suberea ianthelliformis
M Xu, RA Davis, Y Feng, ML Sykes, T Shelper, VM Avery, D Camp, ...
Journal of Natural Products 75 (5), 1001-1005, 2012
Trypanocidal activity of marine natural products
AJ Jones, T Grkovic, ML Sykes, VM Avery
Marine drugs 11 (10), 4058-4082, 2013
A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427
ML Sykes, VM Avery
Parasites & vectors 2 (1), 1-12, 2009
Wilsoniamines A and B: Novel alkaloids from the temperate Australian bryozoan, Amathia wilsoni
AR Carroll, S Duffy, M Sykes, VM Avery
Organic & Biomolecular Chemistry 9 (2), 604-609, 2011
7′,8′-Dihydroobolactone, a typanocidal α-pyrone from the rainforest tree Cryptocarya obovata
RA Davis, O Demirkiran, ML Sykes, VM Avery, L Suraweera, GA Fechner, ...
Bioorganic & medicinal chemistry letters 20 (14), 4057-4059, 2010
3-(Oxazolo [4, 5-b] pyridin-2-yl) anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis
L Ferrins, R Rahmani, ML Sykes, AJ Jones, VM Avery, E Teston, ...
European journal of medicinal chemistry 66, 450-465, 2013
The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement
SD Houston, T Fahrenhorst-Jones, H Xing, BA Chalmers, ML Sykes, ...
Organic & Biomolecular Chemistry 17 (28), 6790-6798, 2019
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