| A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ Y Hashimoto, T Niikura, H Tajima, T Yasukawa, H Sudo, Y Ito, Y Kita, ... Proceedings of the National Academy of Sciences 98 (11), 6336-6341, 2001 | 711 | 2001 |
| Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis M Ikonen, B Liu, Y Hashimoto, L Ma, KW Lee, T Niikura, I Nishimoto, ... Proceedings of the National Academy of Sciences 100 (22), 13042-13047, 2003 | 332 | 2003 |
| Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults Y Hashimoto, T Niikura, Y Ito, H Sudo, M Hata, E Arakawa, Y Abe, Y Kita, ... Journal of Neuroscience 21 (23), 9235-9245, 2001 | 280 | 2001 |
| Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein Y Hashimoto, Y Ito, T Niikura, Z Shao, M Hata, F Oyama, I Nishimoto Biochemical and biophysical research communications 283 (2), 460-468, 2001 | 272 | 2001 |
| Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor α/WSX-1/gp130 Y Hashimoto, M Kurita, S Aiso, I Nishimoto, M Matsuoka Molecular biology of the cell 20 (12), 2864-2873, 2009 | 203 | 2009 |
| Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults H Tajima, T Niikura, Y Hashimoto, Y Ito, Y Kita, K Terashita, K Yamazaki, ... Neuroscience letters 324 (3), 227-231, 2002 | 174 | 2002 |
| A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults T Niikura, Y Hashimoto, H Tajima, M Ishizaka, Y Yamagishi, M Kawasumi, ... European Journal of Neuroscience 17 (6), 1150-1158, 2003 | 168 | 2003 |
| Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults Y Yamagishi, Y Hashimoto, T Niikura, I Nishimoto Peptides 24 (4), 585-595, 2003 | 143 | 2003 |
| Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection Y Hashimoto, H Suzuki, S Aiso, T Niikura, I Nishimoto, M Matsuoka Life sciences 77 (24), 3092-3104, 2005 | 137 | 2005 |
| Involvement of c‐Jun N‐terminal kinase in amyloid precursor protein‐mediated neuronal cell death Y Hashimoto, O Tsuji, T Niikura, Y Yamagishi, M Ishizaka, M Kawasumi, ... Journal of neurochemistry 84 (4), 864-877, 2003 | 128 | 2003 |
| Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants K Kanekura, Y Hashimoto, T Niikura, S Aiso, M Matsuoka, I Nishimoto Journal of Biological Chemistry 279 (18), 19247-19256, 2004 | 121 | 2004 |
| Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin … T Chiba, M Yamada, Y Hashimoto, M Sato, J Sasabe, Y Kita, K Terashita, ... Journal of Neuroscience 25 (44), 10252-10261, 2005 | 118 | 2005 |
| A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant … K Kanekura, Y Hashimoto, Y Kita, J Sasabe, S Aiso, I Nishimoto, ... Journal of biological chemistry 280 (6), 4532-4543, 2005 | 116 | 2005 |
| Characterization of the toxic mechanism triggered by Alzheimer's amyloid‐β peptides via p75 neurotrophin receptor in neuronal hybrid cells E Tsukamoto, Y Hashimoto, K Kanekura, T Niikura, S Aiso, I Nishimoto Journal of neuroscience research 73 (5), 627-636, 2003 | 110 | 2003 |
| S-nitrosothiol depletion in amyotrophic lateral sclerosis CM Schonhoff, M Matsuoka, H Tummala, MA Johnson, AG Estevéz, R Wu, ... Proceedings of the National Academy of Sciences 103 (7), 2404-2409, 2006 | 109 | 2006 |
| Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases Y Hashimoto, H Jiang, T Niikura, Y Ito, A Hagiwara, K Umezawa, Y Abe, ... Journal of Neuroscience 20 (22), 8401-8409, 2000 | 102 | 2000 |
| The cytoplasmic domain of Alzheimer's amyloid-β protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via … Y Hashimoto, T Niikura, T Chiba, E Tsukamoto, H Kadowaki, H Nishitoh, ... Journal of Pharmacology and Experimental Therapeutics 306 (3), 889-902, 2003 | 100* | 2003 |
| Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by … K Terashita, Y Hashimoto, T Niikura, H Tajima, Y Yamagishi, M Ishizaka, ... Journal of Neurochemistry 85 (6), 1521-1538, 2003 | 100 | 2003 |
| Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid‐β peptides via p75NTR/PLAIDD Y Hashimoto, Y Kaneko, E Tsukamoto, H Frankowski, K Kouyama, Y Kita, ... Journal of neurochemistry 90 (3), 549-558, 2004 | 95 | 2004 |
| Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein … T Niikura, Y Hashimoto, T Okamoto, Y Abe, T Yasukawa, M Kawasumi, ... Journal of Neuroscience 21 (6), 1902-1910, 2001 | 86 | 2001 |
