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nikunjkumar patel
nikunjkumar patel
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Year
Model-Based Analysis of Biopharmaceutic Experiments To Improve Mechanistic Oral Absorption Modeling: An Integrated in Vitro in Vivo Extrapolation Perspective …
SM Pathak, A Ruff, ES Kostewicz, N Patel, DB Turner, M Jamei
Molecular pharmaceutics 14 (12), 4305-4320, 2017
792017
Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report
T Heimbach, S Suarez-Sharp, M Kakhi, N Holmstock, A Olivares-Morales, ...
The AAPS Journal 21, 1-15, 2019
732019
In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation, and Precipitation of Posaconazole
B Hens, SM Pathak, A Mitra, N Patel, B Liu, S Patel, M Jamei, J Brouwers, ...
Molecular pharmaceutics 14 (12), 4321-4333, 2017
682017
Prediction of concentration–time profile and its inter-individual variability following the dermal drug absorption
S Polak, C Ghobadi, H Mishra, M Ahamadi, N Patel, M Jamei, ...
Journal of pharmaceutical sciences 101 (7), 2584-2595, 2012
622012
Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug …
M Chetty, RH Rose, K Abduljalil, A Rostami-Hodjegan
Frontiers in pharmacology 5, 115772, 2014
592014
Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria
K Doki, AS Darwich, N Patel, A Rostami-Hodjegan
European journal of pharmaceutical sciences 109, 111-120, 2017
522017
Differences in food effects for 2 weak bases with similar BCS drug-related properties: what is happening in the intestinal lumen?
R Cristofoletti, N Patel, JB Dressman
Journal of Pharmaceutical Sciences 105 (9), 2712-2722, 2016
512016
Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: A case …
N Patel, S Polak, M Jamei, A Rostami-Hodjegan, DB Turner
European Journal of Pharmaceutical Sciences 57, 240-249, 2014
502014
Assessment of bioequivalence of weak base formulations under various dosing conditions using physiologically based pharmacokinetic simulations in virtual populations. Case …
R Cristofoletti, N Patel, JB Dressman
Journal of pharmaceutical sciences 106 (2), 560-569, 2017
492017
Real patient and its virtual twin: application of quantitative systems toxicology modelling in the cardiac safety assessment of citalopram
N Patel, B Wi¶niowska, M Jamei, S Polak
The AAPS Journal 20, 1-10, 2018
342018
Physiologically based pharmacokinetic modeling of transdermal selegiline and its metabolites for the evaluation of disposition differences between healthy and special populations
SK Puttrevu, S Arora, S Polak, NK Patel
Pharmaceutics 12 (10), 942, 2020
262020
Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study
K Fijorek, N Patel, £ Klima, K Stolarz-Skrzypek, K Kawecka-Jaszcz, ...
Theoretical biology and medical modelling 10, 1-11, 2013
262013
Best practices in the development and validation of physiologically based biopharmaceutics modeling. A workshop summary report
N Parrott, S Suarez-Sharp, F Kesisoglou, SM Pathak, D Good, C Wagner, ...
Journal of Pharmaceutical Sciences 110 (2), 584-593, 2021
252021
Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states
C Litou, N Patel, DB Turner, E Kostewicz, M Kuentz, KJ Box, J Dressman
European Journal of Pharmaceutical Sciences 138, 105031, 2019
232019
Conformational polymorphism in sulfonylurea drugs: electronic structure analysis
Y Kasetti, NK Patel, S Sundriyal, PV Bharatam
The Journal of Physical Chemistry B 114 (35), 11603-11611, 2010
232010
Integrating drug-and formulation-related properties with gastrointestinal tract variability using a product-specific particle size approach: case example ibuprofen
R Cristofoletti, B Hens, N Patel, VV Esteban, S Schmidt, J Dressman
Journal of Pharmaceutical Sciences 108 (12), 3842-3847, 2019
222019
Quantitative approach for cardiac risk assessment and interpretation in tuberculosis drug development
S Polak, K Romero, A Berg, N Patel, M Jamei, D Hermann, D Hanna
Journal of Pharmacokinetics and Pharmacodynamics 45 (3), 457-467, 2018
182018
Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept
M Abbasi, BG Small, N Patel, M Jamei, S Polak
Toxicology Mechanisms and Methods 27 (2), 88-99, 2017
172017
Proof of concept in assignment of within-subject variability during virtual bioequivalence studies: propagation of intra-subject variation in gastrointestinal physiology using …
M Bego, N Patel, R Cristofoletti, A Rostami-Hodjegan
The AAPS Journal 24 (1), 21, 2022
162022
Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process
B Mistry, N Patel, M Jamei, A Rostami-Hodjegan, MN Martinez
The AAPS Journal 18, 1144-1158, 2016
152016
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