Model-Based Analysis of Biopharmaceutic Experiments To Improve Mechanistic Oral Absorption Modeling: An Integrated in Vitro in Vivo Extrapolation Perspective … SM Pathak, A Ruff, ES Kostewicz, N Patel, DB Turner, M Jamei Molecular pharmaceutics 14 (12), 4305-4320, 2017 | 79 | 2017 |
Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report T Heimbach, S Suarez-Sharp, M Kakhi, N Holmstock, A Olivares-Morales, ... The AAPS Journal 21, 1-15, 2019 | 73 | 2019 |
In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation, and Precipitation of Posaconazole B Hens, SM Pathak, A Mitra, N Patel, B Liu, S Patel, M Jamei, J Brouwers, ... Molecular pharmaceutics 14 (12), 4321-4333, 2017 | 68 | 2017 |
Prediction of concentration–time profile and its inter-individual variability following the dermal drug absorption S Polak, C Ghobadi, H Mishra, M Ahamadi, N Patel, M Jamei, ... Journal of pharmaceutical sciences 101 (7), 2584-2595, 2012 | 62 | 2012 |
Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug … M Chetty, RH Rose, K Abduljalil, A Rostami-Hodjegan Frontiers in pharmacology 5, 115772, 2014 | 59 | 2014 |
Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria K Doki, AS Darwich, N Patel, A Rostami-Hodjegan European journal of pharmaceutical sciences 109, 111-120, 2017 | 52 | 2017 |
Differences in food effects for 2 weak bases with similar BCS drug-related properties: what is happening in the intestinal lumen? R Cristofoletti, N Patel, JB Dressman Journal of Pharmaceutical Sciences 105 (9), 2712-2722, 2016 | 51 | 2016 |
Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: A case … N Patel, S Polak, M Jamei, A Rostami-Hodjegan, DB Turner European Journal of Pharmaceutical Sciences 57, 240-249, 2014 | 50 | 2014 |
Assessment of bioequivalence of weak base formulations under various dosing conditions using physiologically based pharmacokinetic simulations in virtual populations. Case … R Cristofoletti, N Patel, JB Dressman Journal of pharmaceutical sciences 106 (2), 560-569, 2017 | 49 | 2017 |
Real patient and its virtual twin: application of quantitative systems toxicology modelling in the cardiac safety assessment of citalopram N Patel, B Wi¶niowska, M Jamei, S Polak The AAPS Journal 20, 1-10, 2018 | 34 | 2018 |
Physiologically based pharmacokinetic modeling of transdermal selegiline and its metabolites for the evaluation of disposition differences between healthy and special populations SK Puttrevu, S Arora, S Polak, NK Patel Pharmaceutics 12 (10), 942, 2020 | 26 | 2020 |
Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study K Fijorek, N Patel, £ Klima, K Stolarz-Skrzypek, K Kawecka-Jaszcz, ... Theoretical biology and medical modelling 10, 1-11, 2013 | 26 | 2013 |
Best practices in the development and validation of physiologically based biopharmaceutics modeling. A workshop summary report N Parrott, S Suarez-Sharp, F Kesisoglou, SM Pathak, D Good, C Wagner, ... Journal of Pharmaceutical Sciences 110 (2), 584-593, 2021 | 25 | 2021 |
Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states C Litou, N Patel, DB Turner, E Kostewicz, M Kuentz, KJ Box, J Dressman European Journal of Pharmaceutical Sciences 138, 105031, 2019 | 23 | 2019 |
Conformational polymorphism in sulfonylurea drugs: electronic structure analysis Y Kasetti, NK Patel, S Sundriyal, PV Bharatam The Journal of Physical Chemistry B 114 (35), 11603-11611, 2010 | 23 | 2010 |
Integrating drug-and formulation-related properties with gastrointestinal tract variability using a product-specific particle size approach: case example ibuprofen R Cristofoletti, B Hens, N Patel, VV Esteban, S Schmidt, J Dressman Journal of Pharmaceutical Sciences 108 (12), 3842-3847, 2019 | 22 | 2019 |
Quantitative approach for cardiac risk assessment and interpretation in tuberculosis drug development S Polak, K Romero, A Berg, N Patel, M Jamei, D Hermann, D Hanna Journal of Pharmacokinetics and Pharmacodynamics 45 (3), 457-467, 2018 | 18 | 2018 |
Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept M Abbasi, BG Small, N Patel, M Jamei, S Polak Toxicology Mechanisms and Methods 27 (2), 88-99, 2017 | 17 | 2017 |
Proof of concept in assignment of within-subject variability during virtual bioequivalence studies: propagation of intra-subject variation in gastrointestinal physiology using … M Bego, N Patel, R Cristofoletti, A Rostami-Hodjegan The AAPS Journal 24 (1), 21, 2022 | 16 | 2022 |
Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process B Mistry, N Patel, M Jamei, A Rostami-Hodjegan, MN Martinez The AAPS Journal 18, 1144-1158, 2016 | 15 | 2016 |