Jun Yong Choi
Jun Yong Choi
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Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase
LI McCall, A El Aroussi, JY Choi, DF Vieira, G De Muylder, JB Johnston, ...
PLoS neglected tropical diseases 9 (3), e0003588, 2015
Drug strategies targeting CYP51 in neglected tropical diseases
JY Choi, LM Podust, WR Roush
Chemical Reviews 114 (22), 11242-11271, 2014
Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents
JY Choi, CM Calvet, SS Gunatilleke, C Ruiz, MD Cameron, JH McKerrow, ...
Journal of medicinal chemistry 56 (19), 7651-7668, 2013
Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas aeruginosa Thymidylate Kinase: From Hit to Lead Generation
JY Choi, MS Plummer, J Starr, CR Desbonnet, H Soutter, J Chang, ...
Journal of Medicinal Chemistry 55 (2), 852-870, 2012
4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency
CM Calvet, DF Vieira, JY Choi, D Kellar, MD Cameron, JL Siqueira-Neto, ...
Journal of medicinal chemistry 57 (16), 6989-7005, 2014
Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl) pyrimido [2, 1-α] isoquinolin-4-one
LM Ballou, ES Selinger, JY Choi, DG Drueckhammer, RZ Lin
Journal of Biological Chemistry 282 (33), 24463-24470, 2007
Chemistry and biology of macrolide antiparasitic agents
Y Lee, JY Choi, H Fu, C Harvey, S Ravindran, WR Roush, JC Boothroyd, ...
Journal of medicinal chemistry 54 (8), 2792-2804, 2011
Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51
DF Vieira, JY Choi, CM Calvet, JL Siqueira-Neto, JB Johnston, D Kellar, ...
Journal of medicinal chemistry 57 (23), 10162-10175, 2014
Structure-based design and synthesis of potent and selective matrix metalloproteinase 13 inhibitors
JY Choi, R Fuerst, AM Knapinska, AB Taylor, L Smith, X Cao, PJ Hart, ...
Journal of medicinal chemistry 60 (13), 5816-5825, 2017
Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro
TP Spicer, J Jiang, AB Taylor, JY Choi, PJ Hart, WR Roush, GB Fields, ...
Journal of Medicinal Chemistry 57 (22), 9598-9611, 2014
In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors
SD Wood, W Grant, I Adrados, JY Choi, JM Alburger, DR Duckett, ...
ACS Medicinal Chemistry Letters 8 (12), 1258-1263, 2017
Expanding the Binding Envelope of CYP51 Inhibitors Targeting Trypanosoma cruzi with 4‐Aminopyridyl‐Based Sulfonamide Derivatives
DF Vieira, JY Choi, WR Roush, LM Podust
ChemBioChem 15 (8), 1111-1120, 2014
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi …
CM Calvet, JY Choi, D Thomas, B Suzuki, K Hirata, S Lostracco-Johnson, ...
PLoS neglected tropical diseases 11 (12), e0006132, 2017
R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi
JY Choi, CM Calvet, DF Vieira, SS Gunatilleke, MD Cameron, ...
Acs Medicinal Chemistry Letters 5 (4), 434-439, 2014
Synthesis, biological activity and receptor-based 3-D QSAR study of 3′-N-substituted-3′-N-debenzoylpaclitaxel analogues
EJ Roh, D Kim, JY Choi, BS Lee, CO Lee, CE Song
Bioorganic & medicinal chemistry 10 (10), 3135-3143, 2002
Structure based design of CYP51 inhibitors
J Yong Choi, W R Roush
Current Topics in Medicinal Chemistry 17 (1), 30-39, 2017
Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma–Induced Osteolysis and Reduces Overall Survival
CH Lo, G Shay, JJ McGuire, T Li, KH Shain, JY Choi, R Fuerst, WR Roush, ...
Cancer research 81 (9), 2415-2428, 2021
Development of matrix metalloproteinase-13 inhibitors–A structure-activity/structure-property relationship study
R Fuerst, JY Choi, AM Knapinska, L Smith, MD Cameron, C Ruiz, ...
Bioorganic & medicinal chemistry 26 (18), 4984-4995, 2018
High Level ab Initio Study of Thermal 1, 3-Sigmatropic Shift in CH2 CHCH2X with X= BH2, NH2, and CH3
JY Choi, CK Kim, CK Kim, I Lee
The Journal of Physical Chemistry A 106 (23), 5709-5715, 2002
Campaign to identify agonists of transient receptor potential channels 3 and 2 (TRPML3 & TRPML2)
SA Saldanha, C Grimm, BA Mercer, JY Choi, C Allais, WR Roush, ...
Probe Reports from the NIH Molecular Libraries Program [Internet], 2011
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