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Cláudia Magalhaes Calvet
Cláudia Magalhaes Calvet
Verified email at ioc.fiocruz.br
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Year
Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51
SS Gunatilleke, CM Calvet, JB Johnston, CK Chen, G Erenburg, J Gut, ...
Public Library of Science 6 (7), e1736, 2012
702012
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease
BP Olivieri, JT Molina, SL de Castro, MC Pereira, CM Calvet, JA Urbina, ...
International journal of antimicrobial agents 36 (1), 79-83, 2010
672010
SB-431542, a Transforming Growth Factor β Inhibitor, Impairs Trypanosoma cruzi Infection in Cardiomyocytes and Parasite Cycle Completion
MC Waghabi, M Keramidas, CM Calvet, M Meuser, MNC Soeiro, ...
Antimicrobial agents and chemotherapy 51 (8), 2905-2910, 2007
642007
Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents
JY Choi, CM Calvet, SS Gunatilleke, C Ruiz, MD Cameron, JH McKerrow, ...
Journal of medicinal chemistry 56 (19), 7651-7668, 2013
632013
4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency
CM Calvet, DF Vieira, JY Choi, D Kellar, MD Cameron, JL Siqueira-Neto, ...
Journal of medicinal chemistry 57 (16), 6989-7005, 2014
552014
CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)
A Debnath, CM Calvet, G Jennings, W Zhou, A Aksenov, MR Luth, ...
PLoS neglected tropical diseases 11 (12), e0006104, 2017
522017
Trypanosoma cruzi–cardiomyocyte interaction: role of fibronectin in the recognition process and extracellular matrix expression in vitro and in vivo
CM Calvet, M Meuser, D Almeida, MNL Meirelles, MCS Pereira
Experimental parasitology 107 (1-2), 20-30, 2004
512004
Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target
JW Choy, C Bryant, CM Calvet, PS Doyle, SS Gunatilleke, SSF Leung, ...
Beilstein journal of organic chemistry 9 (1), 15-25, 2013
502013
Efficacy of 2-hydroxy-3-phenylsulfanylmethyl-[1, 4]-naphthoquinone derivatives against different Trypanosoma cruzi discrete type units: Identification of a promising hit compound
LS Lara, CS Moreira, CM Calvet, GC Lechuga, RS Souza, ...
European Journal of Medicinal Chemistry 144, 572-581, 2018
422018
Heparan Sulfate Proteoglycans Mediate the Invasion of Cardiomyocytes by Trypanosoma cruzi
CM Calvet, L Toma, FR De Souza, MDENSL DE MEIRELLES, ...
Journal of Eukaryotic Microbiology 50 (2), 97-103, 2003
392003
Hydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease
DR de Menezes, CM Calvet, GC Rodrigues, MC de Souza Pereira, ...
Journal of Enzyme Inhibition and Medicinal Chemistry 31 (6), 964-973, 2016
372016
Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51
DF Vieira, JY Choi, CM Calvet, JL Siqueira-Neto, JB Johnston, D Kellar, ...
Journal of medicinal chemistry 57 (23), 10162-10175, 2014
352014
Involvement of host cell heparan sulfate proteoglycan in Trypanosoma cruzi amastigote attachment and invasion
R Bambino-Medeiros, CM Calvet, D Vicente, L Toma, MA Krieger, ...
Parasitology 138 (5), 593-601, 2011
342011
Current understanding of the Trypanosoma cruzi-cardiomyocyte interaction
CM Calvet, TG Melo, LR Garzoni, FOR Oliveira Jr, DTS Neto, M NSL, ...
Frontiers in immunology 3, 327, 2012
322012
Trypanosoma cruzi heparin-binding proteins mediate the adherence of epimastigotes to the midgut epithelial cells of Rhodnius prolixus
CR Alves, F Souza-Silva, CM Calvet, LMC Côrtes, MS Gonzalez, L Toma, ...
Parasitology 139 (6), 735-743, 2012
292012
Trypanosoma cruzi heparin-binding proteins and the nature of the host cell heparan sulfate-binding domain
FOR de Oliveira Jr, CR Alves, CM Calvet, L Toma, RI Bouças, HB Nader, ...
Microbial pathogenesis 44 (4), 329-338, 2008
292008
Trypanosoma cruzi heparin-binding proteins and the nature of the host cell heparan sulfate-binding domain
FOR de Oliveira Jr, CR Alves, CM Calvet, L Toma, RI Bouças, HB Nader, ...
Microbial pathogenesis 44 (4), 329-338, 2008
292008
Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole Derivatives as Antiprotozoal Agents
F Saccoliti, VN Madia, V Tudino, A De Leo, L Pescatori, A Messore, ...
Journal of Medicinal Chemistry 62 (3), 1330-1347, 2019
282019
Rapid chagas disease drug target discovery using directed evolution in drug-sensitive yeast
S Ottilie, GM Goldgof, CM Calvet, GK Jennings, G LaMonte, J Schenken, ...
ACS chemical biology 12 (2), 422-434, 2017
282017
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi …
CM Calvet, JY Choi, D Thomas, B Suzuki, K Hirata, S Lostracco-Johnson, ...
PLoS neglected tropical diseases 11 (12), e0006132, 2017
242017
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