Jair L. Siqueira-Neto
Jair L. Siqueira-Neto
Associate Professor
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Visceral leishmaniasis treatment: what do we have, what do we need and how to deliver it?
LH Freitas-Junior, E Chatelain, HA Kim, JL Siqueira-Neto
International Journal for Parasitology: Drugs and Drug Resistance 2, 11-19, 2012
Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds
JL Siqueira-Neto, OR Song, H Oh, JH Sohn, G Yang, J Nam, J Jang, ...
PLoS neglected tropical diseases 4 (5), e675, 2010
An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages
JL Siqueira-Neto, S Moon, J Jang, G Yang, C Lee, HK Moon, E Chatelain, ...
PLoS neglected tropical diseases 6 (6), e1671, 2012
Cysteine proteases in protozoan parasites
JL Siqueira-Neto, A Debnath, LI McCall, JA Bernatchez, M Ndao, ...
PLoS neglected tropical diseases 12 (8), e0006512, 2018
Zika virus targets glioblastoma stem cells through a SOX2-integrin αvβ5 axis
Z Zhu, P Mesci, JA Bernatchez, RC Gimple, X Wang, ST Schafer, ...
Cell stem cell 26 (2), 187-204. e10, 2020
Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase
LI McCall, A El Aroussi, JY Choi, DF Vieira, G De Muylder, JB Johnston, ...
PLoS neglected tropical diseases 9 (3), e0003588, 2015
Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma
SC Mack, I Singh, X Wang, R Hirsch, Q Wu, R Villagomez, JA Bernatchez, ...
Journal of Experimental Medicine 216 (5), 1071-1090, 2019
Genome-directed lead discovery: biosynthesis, structure elucidation, and biological evaluation of two families of polyene macrolactams against Trypanosoma brucei
CJ Schulze, MS Donia, JL Siqueira-Neto, D Ray, JA Raskatov, RE Green, ...
ACS chemical biology 10 (10), 2373-2381, 2015
Drugs for the treatment of Zika virus infection
JA Bernatchez, LT Tran, J Li, Y Luan, JL Siqueira-Neto, R Li
Journal of medicinal chemistry 63 (2), 470-489, 2019
Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery
S Ekins, J Lage de Siqueira-Neto, LI McCall, M Sarker, M Yadav, ...
PLoS neglected tropical diseases 9 (6), e0003878, 2015
A clinical-stage cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells
DM Mellott, CT Tseng, A Drelich, P Fajtová, BC Chenna, DH Kostomiris, ...
ACS chemical biology 16 (4), 642-650, 2021
Blocking Zika virus vertical transmission
P Mesci, A Macia, SM Moore, SA Shiryaev, A Pinto, CT Huang, L Tejwani, ...
Scientific reports 8 (1), 1218, 2018
Open drug discovery for the Zika virus
S Ekins, D Mietchen, M Coffee, TP Stratton, JS Freundlich, ...
F1000Research 5, 2016
Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni …
NC Fonseca, LF da Cruz, F da Silva Villela, GA do Nascimento Pereira, ...
Antimicrobial Agents and Chemotherapy 59 (5), 2666-2677, 2015
Design, synthesis, molecular docking and biological evaluation of thiophen-2-iminothiazolidine derivatives for use against Trypanosoma cruzi
EF Silva-Júnior, EPS Silva, PHB França, JPN Silva, EO Barreto, EB Silva, ...
Bioorganic & medicinal chemistry 24 (18), 4228-4240, 2016
4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency
CM Calvet, DF Vieira, JY Choi, D Kellar, MD Cameron, JL Siqueira-Neto, ...
Journal of medicinal chemistry 57 (16), 6989-7005, 2014
Current and future chemotherapy for Chagas disease
L Gaspar, C B Moraes, L H Freitas-Junior, S Ferrari, L Costantino, ...
Current medicinal chemistry 22 (37), 4293-4312, 2015
Synthesis and biological evaluation of 2, 3-dihydroimidazo [1, 2-a] benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi
S Oh, S Kim, S Kong, G Yang, N Lee, D Han, J Goo, JL Siqueira-Neto, ...
European Journal of Medicinal Chemistry 84, 395-403, 2014
Proteomic-based approach to gain insight into reprogramming of THP-1 cells exposed to Leishmania donovani over an early temporal window
AK Singh, RK Pandey, JL Siqueira-Neto, YJ Kwon, LH Freitas-Junior, ...
Infection and immunity 83 (5), 1853-1868, 2015
The putative telomerase reverse transcriptase component of Leishmania amazonensis: gene cloning and characterization
MA Giardini, CBB Lira, FF Conte, LR Camillo, JL de Siqueira Neto, ...
Parasitology research 98, 447-454, 2006
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