Robert Wykes
Robert Wykes
UCL Institute of Neurology
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Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy
RC Wykes, JH Heeroma, L Mantoan, K Zheng, DC MacDonald, ...
Science translational medicine 4 (161), 161ra152-161ra152, 2012
Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells
K Wareham, C Vial, RCE Wykes, P Bradding, EP Seward
British journal of pharmacology 157 (7), 1215-1224, 2009
Functional transient receptor potential melastatin 7 channels are critical for human mast cell survival
RCE Wykes, M Lee, SM Duffy, W Yang, EP Seward, P Bradding
The Journal of Immunology 179 (6), 4045-4052, 2007
Gene therapy in epilepsy—is it time for clinical trials?
DM Kullmann, S Schorge, MC Walker, RC Wykes
Nature Reviews Neurology 10 (5), 300-304, 2014
Epilepsy gene therapy using an engineered potassium channel
A Snowball, E Chabrol, RC Wykes, T Shekh-Ahmad, JH Cornford, A Lieb, ...
Journal of neuroscience 39 (16), 3159-3169, 2019
Focal cortical seizures start as standing waves and propagate respecting homotopic connectivity
LF Rossi, RC Wykes, DM Kullmann, M Carandini
Nature communications 8 (1), 217, 2017
Optogenetic approaches to treat epilepsy
RC Wykes, DM Kullmann, I Pavlov, V Magloire
Journal of neuroscience methods 260, 215-220, 2016
Gene therapy and editing: Novel potential treatments for neuronal channelopathies
RC Wykes, G Lignani
Neuropharmacology 132, 108-117, 2018
Full-bandwidth electrophysiology of seizures and epileptiform activity enabled by flexible graphene microtransistor depth neural probes
A Bonaccini Calia, E Masvidal-Codina, TM Smith, N Schäfer, D Rathore, ...
Nature Nanotechnology 17 (3), 301-309, 2022
Seizures and disturbed brain potassium dynamics in the leukodystrophy megalencephalic leukoencephalopathy with subcortical cysts
M Dubey, E Brouwers, EMC Hamilton, O Stiedl, M Bugiani, H Koch, ...
Annals of Neurology 83 (3), 636-649, 2018
Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice
R Wykes, A Kalmbach, M Eliava, J Waters
Neurobiology of aging 33 (8), 1609-1623, 2012
Differential regulation of endogenous N-and P/Q-type Ca2+ channel inactivation by Ca2+/calmodulin impacts on their ability to support exocytosis in chromaffin cells
RCE Wykes, CS Bauer, SU Khan, JL Weiss, EP Seward
Journal of Neuroscience 27 (19), 5236-5248, 2007
Gene therapy in status epilepticus
MC Walker, S Schorge, DM Kullmann, RC Wykes, JH Heeroma, ...
Epilepsia 54, 43-45, 2013
WONOEP appraisal: Network concept from an imaging perspective
RC Wykes, HM Khoo, L Caciagli, H Blumenfeld, P Golshani, J Kapur, ...
Epilepsia 60 (7), 1293-1305, 2019
Adiabatic dynamic causal modelling
A Jafarian, P Zeidman, RC Wykes, M Walker, KJ Friston
NeuroImage 238, 118243, 2021
The enlightened brain: novel imaging methods focus on epileptic networks at multiple scales
LF Rossi, DM Kullmann, RC Wykes
Frontiers in cellular neuroscience 12, 82, 2018
Semiology, clustering, periodicity and natural history of seizures in an experimental occipital cortical epilepsy model
BL Chang, M Leite, A Snowball, A Lieb, E Chabrol, MC Walker, ...
Disease Models & Mechanisms 11 (12), dmm036194, 2018
Characterization of optogenetically-induced cortical spreading depression in awake mice using graphene micro-transistor arrays
E Masvidal-Codina, TM Smith, D Rathore, Y Gao, X Illa, E Prats-Alfonso, ...
Journal of Neural Engineering 18 (5), 055002, 2021
Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models
JL Tosh, ER Rhymes, P Mumford, HT Whittaker, LJ Pulford, SJ Noy, ...
Scientific Reports 11 (1), 5736, 2021
Targeting firing rate neuronal homeostasis can prevent seizures
F Mulroe, WH Lin, C Mackenzie-Gray Scott, N Aourz, YN Fan, G Coutts, ...
Disease models & mechanisms 15 (10), dmm049703, 2022
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