Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket A Donnelly, BSJ Blagg Current medicinal chemistry 15 (26), 2702-2717, 2008 | 380 | 2008 |
Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90 JA Burlison, L Neckers, AB Smith, A Maxwell, BSJ Blagg Journal of the American Chemical Society 128 (48), 15529-15536, 2006 | 281 | 2006 |
Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation BSJ Blagg, TD Kerr Medicinal research reviews 26 (3), 310-338, 2006 | 233 | 2006 |
Hsp90 inhibitors identified from a library of novobiocin analogues XM Yu, G Shen, L Neckers, H Blake, J Holzbeierlein, B Cronk, BSJ Blagg Journal of the American Chemical Society 127 (37), 12778-12779, 2005 | 222 | 2005 |
A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors J Zhou, C Gelot, C Pantelidou, A Li, H Yücel, RE Davis, A Färkkilä, ... Nature cancer 2 (6), 598-610, 2021 | 210 | 2021 |
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function M Mollapour, S Tsutsumi, AC Donnelly, K Beebe, MJ Tokita, MJ Lee, ... Molecular cell 37 (3), 333-343, 2010 | 195 | 2010 |
Gedunin, a novel Hsp90 inhibitor: semisynthesis of derivatives and preliminary structure− activity relationships GEL Brandt, MD Schmidt, TE Prisinzano, BSJ Blagg Journal of medicinal chemistry 51 (20), 6495-6502, 2008 | 191 | 2008 |
The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity AC Donnelly, JR Mays, JA Burlison, JT Nelson, G Vielhauer, ... The Journal of organic chemistry 73 (22), 8901-8920, 2008 | 186 | 2008 |
Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents H Zhao, AC Donnelly, BR Kusuma, GEL Brandt, D Brown, RA Rajewski, ... Journal of medicinal chemistry 54 (11), 3839-3853, 2011 | 185 | 2011 |
E. coli MEP Synthase: Steady-State Kinetic Analysis and Substrate Binding AT Koppisch, DT Fox, BSJ Blagg, CD Poulter Biochemistry 41 (1), 236-243, 2002 | 172 | 2002 |
Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis*♦ CA Patwardhan, A Fauq, LB Peterson, C Miller, BSJ Blagg, A Chadli Journal of Biological Chemistry 288 (10), 7313-7325, 2013 | 161 | 2013 |
Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines JA Burlison, C Avila, G Vielhauer, DJ Lubbers, J Holzbeierlein, BSJ Blagg The Journal of organic chemistry 73 (6), 2130-2137, 2008 | 161 | 2008 |
Anticancer inhibitors of Hsp90 function: beyond the usual suspects G Garg, A Khandelwal, BSJ Blagg Advances in cancer research 129, 51-88, 2016 | 154 | 2016 |
A non-toxic Hsp90 inhibitor protects neurons from Aβ-induced toxicity S Ansar, JA Burlison, MK Hadden, XM Yu, KE Desino, J Bean, L Neckers, ... Bioorganic & medicinal chemistry letters 17 (7), 1984-1990, 2007 | 153 | 2007 |
Gambogic acid, a natural product inhibitor of Hsp90 J Davenport, JR Manjarrez, L Peterson, B Krumm, BSJ Blagg, RL Matts Journal of natural products 74 (5), 1085-1092, 2011 | 144 | 2011 |
Intramolecular Diels− Alder and tandem intramolecular Diels− Alder/1, 3-dipolar cycloaddition reactions of 1, 3, 4-oxadiazoles GD Wilkie, GI Elliott, BSJ Blagg, SE Wolkenberg, DR Soenen, MM Miller, ... Journal of the American Chemical Society 124 (38), 11292-11294, 2002 | 136 | 2002 |
Old and new approaches to target the Hsp90 chaperone J Sanchez, TR Carter, MS Cohen, BSJ Blagg Current cancer drug targets 20 (4), 253-270, 2020 | 134 | 2020 |
Intramolecular Diels− Alder/1, 3-dipolar cycloaddition cascade of 1, 3, 4-oxadiazoles GI Elliott, JR Fuchs, BSJ Blagg, H Ishikawa, H Tao, ZQ Yuan, DL Boger Journal of the American Chemical Society 128 (32), 10589-10595, 2006 | 130 | 2006 |
Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells JD Eskew, T Sadikot, P Morales, A Duren, I Dunwiddie, M Swink, X Zhang, ... BMC cancer 11, 1-16, 2011 | 121 | 2011 |
Elucidation of the Hsp90 C-terminal inhibitor binding site RL Matts, A Dixit, LB Peterson, L Sun, S Voruganti, P Kalyanaraman, ... ACS chemical biology 6 (8), 800-807, 2011 | 118 | 2011 |