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Case W. McNamara
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Spiroindolones, a potent compound class for the treatment of malaria
M Rottmann, C McNamara, BKS Yeung, MCS Lee, B Zou, B Russell, ...
science 329 (5996), 1175-1180, 2010
11162010
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
D Plouffe, A Brinker, C McNamara, K Henson, N Kato, K Kuhen, A Nagle, ...
Proceedings of the National Academy of Sciences 105 (26), 9059-9064, 2008
4862008
Targeting Plasmodium PI(4)K to eliminate malaria
CW McNamara, MCS Lee, CS Lim, SH Lim, J Roland, A Nagle, O Simon, ...
Nature 504 (7479), 248-253, 2013
3852013
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
S Meister, DM Plouffe, KL Kuhen, GMC Bonamy, T Wu, SW Barnes, ...
Science 334 (6061), 1372-1377, 2011
3332011
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
N Kato, T Sakata, G Breton, KG Le Roch, A Nagle, C Andersen, ...
Nature chemical biology 4 (6), 347-356, 2008
2372008
Selective and specific inhibition of the Plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin
D Hoepfner, CW McNamara, CS Lim, C Studer, R Riedl, T Aust, ...
Cell host & microbe 11 (6), 654-663, 2012
2122012
Na+ regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials
NJ Spillman, RJW Allen, CW McNamara, BKS Yeung, EA Winzeler, ...
Cell host & microbe 13 (2), 227-237, 2013
2092013
Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families
SER Bopp, MJ Manary, AT Bright, GL Johnston, NV Dharia, FL Luna, ...
PLoS genetics 9 (2), e1003293, 2013
2072013
M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition
X Lauth, M von Köckritz-Blickwede, CW McNamara, S Myskowski, ...
Journal of innate immunity 1 (3), 202-214, 2009
1982009
Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence
C McNamara, AS Zinkernagel, P Macheboeuf, MW Cunningham, V Nizet, ...
Science 319 (5868), 1405-1408, 2008
1652008
The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis
J Janes, ME Young, E Chen, NH Rogers, S Burgstaller-Muehlbacher, ...
Proceedings of the National Academy of Sciences 115 (42), 10750-10755, 2018
1302018
A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
A Roth, SP Maher, AJ Conway, R Ubalee, V Chaumeau, C Andolina, ...
Nature communications 9 (1), 1837, 2018
1202018
Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design
MB Harbut, BA Patel, BKS Yeung, CW McNamara, AT Bright, J Ballard, ...
Proceedings of the National Academy of Sciences 109 (52), 21486-21491, 2012
982012
A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor
T Nam, CW McNamara, S Bopp, NV Dharia, S Meister, GMC Bonamy, ...
ACS chemical biology 6 (11), 1214-1222, 2011
962011
A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis
MS Love, FC Beasley, RS Jumani, TM Wright, AK Chatterjee, CD Huston, ...
PLoS neglected tropical diseases 11 (2), e0005373, 2017
952017
High-throughput luciferase-based assay for the discovery of therapeutics that prevent malaria
J Swann, V Corey, CA Scherer, N Kato, E Comer, M Maetani, ...
ACS infectious diseases 2 (4), 281-293, 2016
852016
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials
Y Antonova-Koch, S Meister, M Abraham, MR Luth, S Ottilie, AK Lukens, ...
Science 362 (6419), eaat9446, 2018
812018
Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials
EL Flannery, CW McNamara, SW Kim, TS Kato, F Li, CH Teng, ...
ACS chemical biology 10 (2), 413-420, 2015
812015
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
B Baragaña, B Forte, R Choi, S Nakazawa Hewitt, JA Bueren-Calabuig, ...
Proceedings of the National Academy of Sciences 116 (14), 7015-7020, 2019
722019
KAI407, a Potent Non-8-Aminoquinoline Compound That Kills Plasmodium cynomolgi Early Dormant Liver Stage Parasites In Vitro
AM Zeeman, SM van Amsterdam, CW McNamara, ...
Antimicrobial agents and chemotherapy 58 (3), 1586-1595, 2014
702014
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