| Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata KL Rinehart, TG Holt, NL Fregeau, JG Stroh, PA Keifer, F Sun, LH Li, ... The Journal of Organic Chemistry 55 (15), 4512-4515, 1990 | 783* | 1990 |
| Eudistomins AQ,. beta.-carbolines from the antiviral Caribbean tunicate Eudistoma olivaceum KL Rinehart Jr, J Kobayashi, GC Harbour, J Gilmore, M Mascal, TG Holt, ... Journal of the American Chemical Society 109 (11), 3378-3387, 1987 | 318 | 1987 |
| Thiostrepton-induced gene expression in Streptomyces lividans T Murakami, TG Holt, CJ Thompson Journal of bacteriology 171 (3), 1459-1466, 1989 | 263 | 1989 |
| Bioactive compounds from aquatic and terrestrial sources KL Rinehart, TG Holt, NL Fregeau, PA Keifer, GR Wilson, TJ Perun Jr, ... Journal of natural products 53 (4), 771-792, 1990 | 198 | 1990 |
| Nucleotide sequence analysis reveals linked N-acetyl hydrolase, thioesterase, transport, and regulatory genes encoded by the bialaphos biosynthetic gene cluster of Streptomyces … A Raibaud, M Zalacain, TG Holt, R Tizard, CJ Thompson Journal of bacteriology 173 (14), 4454-4463, 1991 | 111 | 1991 |
| Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats HC Shen, FX Ding, Q Deng, LC Wilsie, ML Krsmanovic, AK Taggart, ... Journal of medicinal chemistry 52 (8), 2587-2602, 2009 | 77 | 2009 |
| Global changes in gene expression related to antibiotic synthesis in Streptomyces hygroscopicus TG Holt, C Chang, C Laurent‐Winter, T Murakami, JI Garrels, JE Davies, ... Molecular microbiology 6 (8), 969-980, 1992 | 72 | 1992 |
| Characterization of the covalent binding of thiostrepton to a thiostrepton-induced protein from Streptomyces lividans ML Chiu, M Folcher, P Griffin, T Holt, T Klatt, CJ Thompson Biochemistry 35 (7), 2332-2341, 1996 | 69 | 1996 |
| Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith K Rinehart, S Ryuichi, TG Holt US Patent 5,256,663, 1993 | 57 | 1993 |
| Biologically active natural products KL Rinehart, R Sakai, TG Holt, NL Fregeau, TJ Perun Jr, DS Seigler, ... Pure and applied chemistry 62 (7), 1277-1280, 1990 | 55 | 1990 |
| Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a … HC Shen, FX Ding, S Raghavan, Q Deng, S Luell, MJ Forrest, ... Journal of medicinal chemistry 53 (6), 2666-2670, 2010 | 54 | 2010 |
| Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor HC Shen, FX Ding, S Luell, MJ Forrest, E Carballo-Jane, KK Wu, TJ Wu, ... Journal of medicinal chemistry 50 (25), 6303-6306, 2007 | 51 | 2007 |
| Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications TG Holt, BK Choi, NS Geoghagen, KK Jensen, Q Luo, WA LaMarr, ... ASSAY and Drug Development Technologies 7 (5), 495-506, 2009 | 45 | 2009 |
| Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists S Raghavan, GS Tria, HC Shen, FX Ding, AK Taggart, N Ren, LC Wilsie, ... Bioorganic & Medicinal Chemistry Letters 18 (11), 3163-3167, 2008 | 40 | 2008 |
| 2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity R Berger, C Zhu, AR Hansen, B Harper, Z Chen, TG Holt, J Hubert, ... Bioorganic & medicinal chemistry letters 18 (17), 4833-4837, 2008 | 30 | 2008 |
| Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice KK Jensen, NS Geoghagen, L Jin, TG Holt, Q Luo, L Malkowitz, W Ni, ... European journal of pharmacology 650 (1), 86-93, 2011 | 27 | 2011 |
| Ecteinascidin-729, ecteinascidin-743, ecteinascidin-745, ecteinascidin-759a, ecteinascidin-759b, and ecteinascidin-770-potent antitumor agents from the Caribbean Tunicate … KL Rinehart, TG Holt, NL Fregeau, JG Stroh, PA Keifer, F Sun, LH Li, ... Journal of Organic Chemistry 55 (15), 4512-4515, 1990 | 27 | 1990 |
| Anthranilic acid replacements in a niacin receptor agonist D Schmidt, A Smenton, S Raghavan, H Shen, FX Ding, E Carballo-Jane, ... Bioorganic & medicinal chemistry letters 20 (11), 3426-3430, 2010 | 26 | 2010 |
| Discovery of imidazole carboxamides as potent and selective CCK1R agonists C Zhu, AR Hansen, T Bateman, Z Chen, TG Holt, JA Hubert, BV Karanam, ... Bioorganic & medicinal chemistry letters 18 (15), 4393-4396, 2008 | 21 | 2008 |
| Applications of high-resolution tandem FAB mass spectrometry KL Rinehart, TG Holt, NL Fregeau, AL Staley, AG Thompson, KI Harada, ... Biological Mass Spectrometry, eds. Burlingame et al., Elsevier Amsterdam …, 1990 | 18 | 1990 |
