| Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages EL Mills, B Kelly, A Logan, ASH Costa, M Varma, CE Bryant, ... Cell 167 (2), 457-470. e13, 2016 | 1657 | 2016 |
| Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... Nature 556 (7699), 113-117, 2018 | 1272 | 2018 |
| Mitochondria are the powerhouses of immunity EL Mills, B Kelly, LAJ O'Neill Nature immunology 18 (5), 488-498, 2017 | 822 | 2017 |
| Succinate: a metabolic signal in inflammation E Mills, LAJ O’Neill Trends in cell biology 24 (5), 313-320, 2014 | 650 | 2014 |
| Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice C Dempsey, AR Araiz, KJ Bryson, O Finucane, C Larkin, EL Mills, ... Brain, behavior, and immunity 61, 306-316, 2017 | 452 | 2017 |
| Reprogramming mitochondrial metabolism in macrophages as an anti‐inflammatory signal EL Mills, LA O'Neill European journal of immunology 46 (1), 13-21, 2016 | 437 | 2016 |
| Accumulation of succinate controls activation of adipose tissue thermogenesis EL Mills, KA Pierce, MP Jedrychowski, R Garrity, S Winther, S Vidoni, ... Nature 560 (7716), 102-106, 2018 | 435 | 2018 |
| Coupling Krebs cycle metabolites to signalling in immunity and cancer DG Ryan, MP Murphy, C Frezza, HA Prag, ET Chouchani, LA O’Neill, ... Nature metabolism 1 (1), 16-33, 2019 | 316 | 2019 |
| A quantitative tissue-specific landscape of protein redox regulation during aging H Xiao, MP Jedrychowski, DK Schweppe, EL Huttlin, Q Yu, DE Heppner, ... Cell 180 (5), 968-983. e24, 2020 | 259 | 2020 |
| Inflammasome priming in sterile inflammatory disease MN Patel, RG Carroll, S Galván-Peña, EL Mills, R Olden, M Triantafilou, ... Trends in molecular medicine 23 (2), 165-180, 2017 | 257 | 2017 |
| pH-gated succinate secretion regulates muscle remodeling in response to exercise A Reddy, LHM Bozi, OK Yaghi, EL Mills, H Xiao, HE Nicholson, ... Cell 183 (1), 62-75. e17, 2020 | 151 | 2020 |
| UCP1 governs liver extracellular succinate and inflammatory pathogenesis EL Mills, C Harmon, MP Jedrychowski, H Xiao, R Garrity, NV Tran, ... Nature metabolism 3 (5), 604-617, 2021 | 95 | 2021 |
| Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease MV Guillot-Sestier, AR Araiz, V Mela, AS Gaban, E O’Neill, L Joshi, ... Communications biology 4 (1), 711, 2021 | 74 | 2021 |
| Lactate regulates cell cycle by remodelling the anaphase promoting complex W Liu, Y Wang, LHM Bozi, PD Fischer, MP Jedrychowski, H Xiao, T Wu, ... Nature 616 (7958), 790-797, 2023 | 55 | 2023 |
| Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function L Dyck, H Prendeville, M Raverdeau, MM Wilk, RM Loftus, A Douglas, ... Journal of Experimental Medicine 219 (3), 2022 | 52 | 2022 |
| Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase CC Cunningham, E Mills, LA Mielke, LK O'Farrell, E Lavelle, A Mori, ... Clinical immunology 144 (3), 228-236, 2012 | 50 | 2012 |
| Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation EL Mills, C Harmon, MP Jedrychowski, H Xiao, AV Gruszczyk, ... Cell metabolism 34 (1), 140-157. e8, 2022 | 33 | 2022 |
| Repurposing mitochondria from ATP production to ROS generation drives a pro-inflammatory phenotype in macrophages that depends on succinate oxidation by complex II EL Mills, B Kelly, A Logan, ASH Costa, M Varma, CE Bryant, ... Cell 167 (2), 457, 2016 | 32 | 2016 |
| Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages NC Williams, DG Ryan, ASH Costa, EL Mills, MP Jedrychowski, ... Journal of Biological Chemistry 298 (2), 2022 | 25 | 2022 |
| Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor N Darabedian, W Ji, M Fan, S Lin, HS Seo, EV Vinogradova, TM Yaron, ... Nature chemical biology 19 (7), 815-824, 2023 | 17 | 2023 |
