Kelsie L. Thu
Kelsie L. Thu
St. Michael's Hospital
Verified email at - Homepage
Cited by
Cited by
Targeting mitosis in cancer: emerging strategies
C Dominguez-Brauer, KL Thu, JM Mason, H Blaser, MR Bray, TW Mak
Molecular cell 60 (4), 524-536, 2015
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O’Neil, ND Santos, ...
Nature communications 8 (1), 14432, 2017
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell–like properties in cancer cells
K Shien, S Toyooka, H Yamamoto, J Soh, M Jida, KL Thu, S Hashida, ...
Cancer research 73 (10), 3051-3061, 2013
The detection and implication of genome instability in cancer
L Pikor, K Thu, E Vucic, W Lam
Cancer and Metastasis Reviews 32, 341-352, 2013
Mutant IDH1 downregulates ATM and alters DNA repair and sensitivity to DNA damage independent of TET2
S Inoue, WY Li, A Tseng, I Beerman, AJ Elia, SC Bendall, F Lemonnier, ...
Cancer cell 30 (2), 337-348, 2016
Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology
VD Martinez, EA Vucic, KL Thu, R Hubaux, KSS Enfield, LA Pikor, ...
Scientific reports 5 (1), 10423, 2015
DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways
EA Vucic, R Chari, KL Thu, IM Wilson, AM Cotton, JY Kennett, M Zhang, ...
American journal of respiratory cell and molecular biology 50 (5), 912-922, 2014
Translating cancer ‘omics’ to improved outcomes
EA Vucic, KL Thu, K Robison, LA Rybaczyk, R Chari, CE Alvarez, WL Lam
Genome research 22 (2), 188-195, 2012
Targeting the cell cycle in breast cancer: towards the next phase
KL Thu, I Soria-Bretones, TW Mak, DW Cescon
Cell Cycle 17 (15), 1871-1885, 2018
Polycomb-mediated silencing in neuroendocrine prostate cancer
PL Clermont, D Lin, F Crea, R Wu, H Xue, Y Wang, KL Thu, WL Lam, ...
Clinical epigenetics 7, 1-13, 2015
Integrative Genomic Analyses Identify BRF2 as a Novel Lineage-Specific Oncogene in Lung Squamous Cell Carcinoma
WW Lockwood, R Chari, BP Coe, KL Thu, C Garnis, CA Malloff, ...
PLoS medicine 7 (7), e1000315, 2010
CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non–small-cell lung cancer
KW Tam, W Zhang, J Soh, V Stastny, M Chen, H Sun, K Thu, JJ Rios, ...
Journal of thoracic oncology 8 (11), 1378-1388, 2013
Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer
BP Coe, KL Thu, S Aviel-Ronen, EA Vucic, AF Gazdar, S Lam, MS Tsao, ...
PloS one 8 (8), e71670, 2013
Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer
SD Bailey, K Desai, KJ Kron, P Mazrooei, NA Sinnott-Armstrong, ...
Nature genetics 48 (10), 1260-1266, 2016
AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer
SP Kubli, C Bassi, C Roux, A Wakeham, C Göbl, W Zhou, SM Jafari, ...
Proceedings of the National Academy of Sciences 116 (9), 3604-3613, 2019
Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role
PL Clermont, L Sun, F Crea, KL Thu, A Zhang, A Parolia, WL Lam, ...
British journal of cancer 111 (8), 1663-1672, 2014
EZH2 promotes E2F-driven SCLC tumorigenesis through modulation of apoptosis and cell-cycle regulation
R Hubaux, KL Thu, BP Coe, C MacAulay, S Lam, WL Lam
Journal of Thoracic Oncology 8 (8), 1102-1106, 2013
Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers
M Kawakami, LM Mustachio, L Zheng, Y Chen, J Rodriguez-Canales, ...
Proceedings of the National Academy of Sciences 115 (8), 1913-1918, 2018
Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer
PL Clermont, F Crea, YT Chiang, D Lin, A Zhang, JZL Wang, A Parolia, ...
Clinical epigenetics 8 (1), 1-14, 2016
Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability
KL Thu, EA Vucic, R Chari, W Zhang, WW Lockwood, JC English, R Fu, ...
PloS one 7 (3), e33003, 2012
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