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Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas-and TNFR1-induced apoptosis
J Bertin, RC Armstrong, S Ottilie, DA Martin, Y Wang, S Banks, GH Wang, ...
Proceedings of the National Academy of Sciences 94 (4), 1172-1176, 1997
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis
SM Srinivasula, M Ahmad, S Ottilie, F Bullrich, S Banks, Y Wang, ...
Journal of Biological Chemistry 272 (30), 18542-18545, 1997
Dimerization properties of human Bad: Identification of a BH-3 domain and analysis of its binding to mutant Bcl-2 and Bcl-Xl proteins
S Ottilie, JL Diaz, W Horne, J Chang, Y Wang, G Wilson, S Chang, ...
Journal of Biological Chemistry 272 (49), 30866-30872, 1997
Bax-and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.
JM Jürgensmeier, S Krajewski, RC Armstrong, GM Wilson, T Oltersdorf, ...
Molecular biology of the cell 8 (2), 325-339, 1997
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
AN Cowell, ES Istvan, AK Lukens, MG Gomez-Lorenzo, M Vanaerschot, ...
Science 359 (6372), 191-199, 2018
Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.
S Ottilie, PJ Miller, DI Johnson, CL Creasy, MA Sells, S Bagrodia, ...
The EMBO journal 14 (23), 5908-5919, 1995
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials
Y Antonova-Koch, S Meister, M Abraham, MR Luth, S Ottilie, AK Lukens, ...
Science 362 (6419), eaat9446, 2018
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity
GM LaMonte, J Almaliti, B Bibo-Verdugo, L Keller, BY Zou, J Yang, ...
Journal of medicinal chemistry 60 (15), 6721-6732, 2017
Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
MR Luth, P Gupta, S Ottilie, EA Winzeler
ACS infectious diseases 4 (3), 301-314, 2018
Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast
MA Sells, JT Barratt, J Caviston, S Ottilie, E Leberer, J Chernoff
Journal of Biological Chemistry 273 (29), 18490-18498, 1998
The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis
S Ottilie, J Chernoff, G Hannig, CS Hoffman, RL Erikson
Molecular and cellular biology, 1992
A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases.
S Ottilie, J Chernoff, G Hannig, CS Hoffman, RL Erikson
Proceedings of the National Academy of Sciences 88 (8), 3455-3459, 1991
Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris
S Ottilie, F Raulf, A Barnekow, G Hannig, M Schartl
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
J Reader, ME van der Watt, D Taylor, C Le Manach, N Mittal, S Ottilie, ...
Nature communications 12 (1), 269, 2021
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome
SC Xie, DL Gillett, NJ Spillman, C Tsu, MR Luth, S Ottilie, S Duffy, ...
Journal of medicinal chemistry 61 (22), 10053-10066, 2018
Inhibition of resistance-refractory P. falciparum kinase PKG delivers prophylactic, blood stage, and transmission-blocking antiplasmodial activity
M Vanaerschot, JM Murithi, CFA Pasaje, S Ghidelli-Disse, L Dwomoh, ...
Cell chemical biology 27 (7), 806-816. e8, 2020
Combining stage specificity and metabolomic profiling to advance antimalarial drug discovery
JM Murithi, ES Owen, ES Istvan, MCS Lee, S Ottilie, K Chibale, ...
Cell chemical biology 27 (2), 158-171. e3, 2020
MalDA, accelerating malaria drug discovery
T Yang, S Ottilie, ES Istvan, KP Godinez-Macias, AK Lukens, B Baragaña, ...
Trends in parasitology 37 (6), 493-507, 2021
Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor
GM Goldgof, JD Durrant, S Ottilie, E Vigil, KE Allen, F Gunawan, ...
Scientific reports 6 (1), 27806, 2016
Mutational Analysis of Cdc19p, a Schizosaccharomyces pombe MCM Protein
SL Forsburg, DA Sherman, S Ottilie, JR Yasuda, JA Hodson
Genetics 147 (3), 1025-1041, 1997
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