James McKerrow
James McKerrow
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Cited by
Cited by
Cysteine proteases of parasitic organisms
M Sajid, JH McKerrow
Molecular and biochemical parasitology 120 (1), 1-21, 2002
Protease inhibitors targeting coronavirus and filovirus entry
Y Zhou, P Vedantham, K Lu, J Agudelo, R Carrion Jr, JW Nunneley, ...
Antiviral research 116, 76-84, 2015
Tumour necrosis factor α restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice
P Amiri, RM Locksley, TG Parslow, M Sadickt, E Rector, D Ritter, ...
Nature 356 (6370), 604-607, 1992
In vitro antimalarial activity of chalcones and their derivatives
R Li, GL Kenyon, FE Cohen, X Chen, B Gong, JN Dominguez, E Davidson, ...
Journal of medicinal chemistry 38 (26), 5031-5037, 1995
The proteases and pathogenicity of parasitic protozoa
JH McKerrow, E Sun, PJ Rosenthal, J Bouvier
Annual review of microbiology 47 (1), 821-853, 1993
Synthesis and structure− activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain
X Du, C Guo, E Hansell, PS Doyle, CR Caffrey, TP Holler, JH McKerrow, ...
Journal of medicinal chemistry 45 (13), 2695-2707, 2002
Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection
JC Engel, PS Doyle, I Hsieh, JH McKerrow
The Journal of experimental medicine 188 (4), 725-734, 1998
Proteases in parasitic diseases
JH McKerrow, C Caffrey, B Kelly, P Loke, M Sajid
Annu. Rev. Pathol. Mech. Dis. 1, 497-536, 2006
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-β independent
M Kaviratne, M Hesse, M Leusink, AW Cheever, SJ Davies, JH McKerrow, ...
The Journal of Immunology 173 (6), 4020-4029, 2004
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.
PJ Rosenthal, JH McKerrow, M Aikawa, H Nagasawa, JH Leech
The Journal of clinical investigation 82 (5), 1560-1566, 1988
Drug discovery and development for neglected parasitic diseases
AR Renslo, JH McKerrow
Nature chemical biology 2 (12), 701-710, 2006
JA Sakanari, JH Mckerrow
Clinical microbiology reviews 2 (3), 278-284, 1989
Structure-based inhibitor design by using protein models for the development of antiparasitic agents.
CS Ring, E Sun, JH McKerrow, GK Lee, PJ Rosenthal, ID Kuntz, ...
Proceedings of the national academy of Sciences 90 (8), 3583-3587, 1993
The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi.
AE Eakin, AA Mills, G Harth, JH McKerrow, CS Craik
Journal of Biological Chemistry 267 (11), 7411-7420, 1992
Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against Plasmodium falciparum, Trypanosoma brucei, and …
DC Greenbaum, Z Mackey, E Hansell, P Doyle, J Gut, CR Caffrey, ...
Journal of medicinal chemistry 47 (12), 3212-3219, 2004
Parasite proteases.
JH McKerrow
Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor
MH Abdulla, KC Lim, M Sajid, JH McKerrow, CR Caffrey
PLoS medicine 4 (1), e14, 2007
Controlled deamidation of peptides and proteins: an experimental hazard and a possible biological timer
AB Robinson, JH McKerrow, P Cary
Proceedings of the National Academy of Sciences 66 (3), 753-757, 1970
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target
A Debnath, D Parsonage, RM Andrade, C He, ER Cobo, K Hirata, S Chen, ...
Nature medicine 18 (6), 956-960, 2012
The crystal structure of cruzain: a therapeutic target for Chagas' disease
ME McGrath, AE Eakin, JC Engel, JH McKerrow, CS Craik, RJ Fletterick
Journal of molecular biology 247 (2), 251-259, 1995
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