Michael Ohh
Michael Ohh
Professor, University of Toronto
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HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, JM Asara, ...
Science 292 (5516), 464-468, 2001
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein
M Ohh, CW Park, M Ivan, MA Hoffman, TY Kim, LE Huang, N Pavletich, ...
Nature cell biology 2 (7), 423-427, 2000
The updated biology of hypoxia‐inducible factor
SN Greer, JL Metcalf, Y Wang, M Ohh
The EMBO journal 31 (11), 2448-2460, 2012
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
M Ohh, RL Yauch, KM Lonergan, JM Whaley, AO Stemmer-Rachamimov, ...
Molecular cell 1 (7), 959-968, 1998
Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2
KM Lonergan, O Iliopoulos, M Ohh, T Kamura, RC Conaway, ...
Molecular and cellular biology 18 (2), 732-741, 1998
von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
MA Hoffman, M Ohh, H Yang, JM Klco, M Ivan, WG Kaelin Jr
Human molecular genetics 10 (10), 1019-1027, 2001
Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex
MA Maynard, H Qi, J Chung, EHL Lee, Y Kondo, S Hara, RC Conaway, ...
Journal of Biological Chemistry 278 (13), 11032-11040, 2003
Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia
CM Niemeyer, MW Kang, DH Shin, I Furlan, M Erlacher, NJ Bunin, ...
Nature genetics 42 (9), 794-800, 2010
Differential dependence of hypoxia-inducible factors 1α and 2α on mTORC1 and mTORC2
A Toschi, E Lee, N Gadir, M Ohh, DA Foster
Journal of Biological Chemistry 283 (50), 34495-34499, 2008
VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail
AJ Evans, RC Russell, O Roche, TN Burry, JE Fish, VWK Chow, WY Kim, ...
Molecular and cellular biology 27 (1), 157-169, 2007
pVHL19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation
O Iliopoulos, M Ohh, WG Kaelin Jr
Proceedings of the National Academy of Sciences 95 (20), 11661-11666, 1998
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression
RC O'Hagan, M Ohh, G David, IM De Alboran, FW Alt, WG Kaelin, ...
Genes & development 14 (17), 2185-2191, 2000
Human HIF‐3α4 is a dominant‐negative regulator of HIF‐1 and is down‐regulated in renal cell carcinoma
MA Maynard, AJ Evans, T Hosomi, S Hara, MAS Jewett, M Ohh
The FASEB journal 19 (11), 1396-1406, 2005
pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development
NH Stickle, J Chung, JM Klco, RP Hill, WG Kaelin Jr, M Ohh
Molecular and cellular biology 24 (8), 3251-3261, 2004
An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells
M Ohh, WY Kim, JJ Moslehi, Y Chen, V Chau, MA Read, WG Kaelin
EMBO reports 3 (2), 177-182, 2002
Regulation of endocytosis via the oxygen-sensing pathway
Y Wang, O Roche, MS Yan, G Finak, AJ Evans, JL Metcalf, BE Hast, ...
Nature medicine 15 (3), 319-324, 2009
NEDD8 pathways in cancer, Sine Quibus Non
IR Watson, MS Irwin, M Ohh
Cancer cell 19 (2), 168-176, 2011
The role of hypoxia-inducible factors in cancer
MA Maynard, M Ohh
Cellular and molecular life sciences 64 (16), 2170-2180, 2007
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
S Bunda, K Burrell, P Heir, L Zeng, A Alamsahebpour, Y Kano, B Raught, ...
Nature communications 6 (1), 1-12, 2015
Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer
MA Maynard, M Ohh
American journal of nephrology 24 (1), 1-13, 2004
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